Fasano Gaia, Bennardo Luigi, Ruffolo Silvana, Passante Maria, Ambrosio Azzurra Gaia, Napolitano Maddalena, Provenzano Eugenio, Nisticò Steven Paul, Patruno Cataldo
Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
Mariano Santo Hospital, 87100 Cosenza, Italy.
J Clin Med. 2022 Feb 1;11(3):797. doi: 10.3390/jcm11030797.
COVID Vaccine Arm (CVA) is an adverse drug reaction from mRNA vaccine for SARS-CoV-2. CVA is characterized by erythema and edema on the vaccination site (usually deltoid area) that appears from 5 to 10 days after vaccination and is sometimes associated with itching or pain. The exact etiology of CVA is still unclear, but delayed hypersensitivity against an excipient seems to play an essential role in the pathogenesis of the disease. This work performs a systematic literature review on CVA using three different databases containing articles published until 10 November 2021. The literature review includes eight papers reporting single cases or case series of CVA. Moreover, it also addresses, other cutaneous reactions following COVID 19 vaccinations as well as possible differential diagnosis. CVA migrans-like erythema is characterized by a ring-shaped rash in the injection area, which appears some days after the injection and disappears in about 10 days. This reaction may appear more rapidly in subsequent doses.
新冠疫苗接种部位反应（CVA）是一种针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的信使核糖核酸（mRNA）疫苗的药物不良反应。CVA的特征是接种部位（通常为三角肌区域）出现红斑和水肿，在接种疫苗后5至10天出现，有时伴有瘙痒或疼痛。CVA的确切病因尚不清楚，但对辅料的迟发型超敏反应似乎在该疾病的发病机制中起重要作用。这项工作使用三个不同的数据库对CVA进行了系统的文献综述，这些数据库包含截至2021年11月10日发表的文章。文献综述包括八篇报告CVA单例或病例系列的论文。此外，它还涉及新冠疫苗接种后的其他皮肤反应以及可能的鉴别诊断。游走性CVA样红斑的特征是注射部位出现环形皮疹，在注射后数天出现，约10天内消失。这种反应在后续剂量中可能出现得更快。
