卡托普利对水合氯醛麻醉大鼠脑啡肽引起的血压反应的影响。

Effect of captopril on blood pressure responses to enkephalins in chloralose-anaesthetized rats.

作者信息

Geh S L, Nott M W, Majewski H, Rand M J

出版信息

Arch Int Pharmacodyn Ther. 1986 Feb;279(2):282-90.

Abstract

Captopril lowered blood pressure in chloralose-anaesthetized rats and enhanced the depressor responses to metenkephalin and D-Ala-metenkephalinamide to the same extent. Since metenkephalin is a much better substrate than D-Ala-metenkephalinamide for dipeptidylcarboxypeptidase, some mechanism other than inhibition of this enzyme appears to be responsible for the enhancement by captopril of the responses to opioids. When the blood pressure had been lowered by haemorrhage, naloxone was no more effective than saline control in restoring blood pressure. However, when captopril was given after haemorrhage, the blood pressure was further lowered, and then naloxone produced a significant restoration. Hydralazine given after haemorrhage also caused a further lowering of blood pressure, then naloxone produced a lesser restoration of blood pressure than in haemorrhage plus captopril experiments. The results suggest that release of endogenous opioids may contribute to the fall in blood pressure upon bleeding.

摘要

卡托普利可降低用氯醛糖麻醉大鼠的血压，并同等程度地增强对甲硫氨酸脑啡肽和D-丙氨酸-甲硫氨酸脑啡肽酰胺的降压反应。由于甲硫氨酸脑啡肽比D-丙氨酸-甲硫氨酸脑啡肽酰胺是二肽基羧肽酶更好的底物，卡托普利增强对阿片类药物反应的机制似乎不是抑制该酶。当通过出血使血压降低时，纳洛酮在恢复血压方面并不比生理盐水对照更有效。然而，出血后给予卡托普利，血压会进一步降低，然后纳洛酮可使血压显著恢复。出血后给予肼屈嗪也会导致血压进一步降低，然后纳洛酮使血压恢复的程度小于出血加卡托普利实验中的恢复程度。结果表明，内源性阿片类物质的释放可能导致出血时血压下降。