National Centre for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, 20126 Milan, Italy.
Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.
Int J Environ Res Public Health. 2022 Jan 19;19(3):1073. doi: 10.3390/ijerph19031073.
Using the knowledge gained during the first eleven months of the vaccine campaign in Lombardy, Italy, we provide an overview of the benefits of using reliable, complete, and rapidly available observational data to monitor the progress of the vaccine strategy.
A population-based platform was implemented by linking four registries reporting individual data on: (i) date, type, and dose of vaccine dispensed; (ii) SARS-CoV-2 infections and hospital admissions and deaths due to COVID-19; (iii) inpatient diagnoses and outpatient services supplied by the Regional Health Services (RHS); and the (iv) health registry reporting and updating data on patient status. Background, methods, findings, and implications of eight COVID-19 relevant questions are reported.
Before starting the vaccine campaign, we identified high-risk individuals who need to be prioritized. During the vaccine campaign, we: (i) monitored the trend in the speed of the vaccine campaign progression and the number of prevented clinical outcomes; (ii) verified that available vaccines work in real-life, assessed their effectiveness-harm profile, and measured their reduced effectiveness against the delta variant. Finally, we studied the reduced effectiveness of the vaccine over time and identified risk factors of post-vaccine infection and severe illness.
The correct use of rapidly available observational data of good quality and completeness generates reliable evidence to promptly inform patients and policymakers.
利用意大利伦巴第大区疫苗接种运动前 11 个月获得的知识，我们概述了利用可靠、完整且快速可用的观察数据来监测疫苗接种策略进展的好处。
通过链接四个报告个体数据的登记处，实施了一项基于人群的平台：（i）疫苗分发的日期、类型和剂量；（ii）SARS-CoV-2 感染以及 COVID-19 导致的住院和死亡；（iii）区域卫生服务机构（RHS）提供的住院诊断和门诊服务；以及（iv）报告和更新患者状况数据的健康登记处。报告了与八个 COVID-19 相关问题的背景、方法、发现和意义。
在开始疫苗接种运动之前，我们确定了需要优先考虑的高风险人群。在疫苗接种运动期间，我们：（i）监测疫苗接种运动进展速度和预防临床结果数量的趋势；（ii）验证现有疫苗在现实生活中的有效性，评估其有效性-危害状况，并衡量其对 delta 变异体的有效性降低；最后，我们研究了疫苗随时间的有效性降低情况，并确定了疫苗接种后感染和严重疾病的风险因素。
正确使用高质量和完整性的快速可用观察数据可以生成可靠的证据，以便及时为患者和政策制定者提供信息。
