Molnár D, Székely M
Biol Neonate. 1986;49(2):102-8. doi: 10.1159/000242518.
The metabolic and hormonal effects of Escherichia coli endotoxin injected intraperitoneally (IP) or into the cerebral ventricles (ICV) and that of passive hyperthermia were studied in rabbits aged 6-10 days. Irrespective of the route of administration, endotoxin caused a transient rise in blood glucose with a simultaneous rise in plasma insulin. In contrast, only in the IP, but not in the ICV group, the endotoxin resulted in a rise of the free fatty acid and a fall in the ketone body concentrations by the second hour. The blood level of pyruvate, lactate, alanine and glycerol was not altered by endotoxin. No parameter was affected by the injection of saline or passive hyperthermia.
对6 - 10日龄的家兔，研究了腹腔内（IP）或脑室内（ICV）注射大肠杆菌内毒素以及被动热疗的代谢和激素效应。无论给药途径如何，内毒素都会导致血糖短暂升高，同时血浆胰岛素水平升高。相比之下，仅在腹腔注射组而非脑室内注射组中，内毒素在第二小时导致游离脂肪酸升高和酮体浓度下降。内毒素未改变丙酮酸、乳酸、丙氨酸和甘油的血药浓度。注射生理盐水或被动热疗对任何参数均无影响。
