Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan.
Department of Medical Research, Tri-Service General Hospital, Taipei 11490, Taiwan.
Int J Environ Res Public Health. 2022 Jan 24;19(3):1289. doi: 10.3390/ijerph19031289.
To investigate whether central sleep apnea (CSA) is associated with an increased risk of obesity.
From 1 January 2000 to 31 December 2015, we screened 24,363 obese patients from the 2005 longitudinal health insurance database, which is part of the Taiwan National Health Insurance Research Database. From the same database, 97,452 non-obese patients were also screened out. Age, gender, and index dates were matched. Multiple logistic regression was used to analyze the previous exposure risk of obese and CSA patients. A -value of <0.05 was considered significant.
Obese patients were more likely to be exposed to CSA than non-obese patients would (AOR = 2.234, 95% CI = 1.483-4.380, < 0.001). In addition, the closeness of the exposure time to the index time is positively correlated with the severity of obesity and has a dose-response effect (CSA exposure < 1 year, AOR = 2.386; CSA exposure ≥ 1 year and <5 years, AOR = 1.725; CSA exposure time ≥ 5 years, AOR = 1.422). The CSA exposure time of obese patients was 1.693 times that of non-obese patients. Longer exposure time is associated with more severe obesity and has a dose-response effect (CSA exposure < 1 year, AOR = 1.420; CSA exposure ≥ 1 year and <5 years, AOR = 2.240; CSA ≥ 5 years, AOR = 2.863).
In this case-control study, patients with CSA had a significantly increased risk of obesity. Long-term exposure to CSA and obesity is more likely and has a dose-response effect.
探讨中枢性睡眠呼吸暂停（CSA）是否与肥胖风险增加相关。
我们从 2005 年纵向健康保险数据库（台湾全民健康保险研究数据库的一部分）中筛选了 2000 年 1 月 1 日至 2015 年 12 月 31 日期间的 24363 例肥胖患者，并从同一数据库中筛选出 97452 例非肥胖患者。两组患者的年龄、性别和索引日期相匹配。采用多因素 logistic 回归分析肥胖和 CSA 患者的既往暴露风险。当 P 值<0.05 时，认为差异有统计学意义。
肥胖患者比非肥胖患者更有可能接触 CSA（OR=2.234，95%CI=1.483-4.380，P<0.001）。此外，暴露时间与索引时间的接近程度与肥胖的严重程度呈正相关，且存在剂量-反应关系（CSA 暴露<1 年，OR=2.386；CSA 暴露≥1 年且<5 年，OR=1.725；CSA 暴露时间≥5 年，OR=1.422）。肥胖患者的 CSA 暴露时间是非肥胖患者的 1.693 倍。较长的暴露时间与更严重的肥胖有关，且存在剂量-反应关系（CSA 暴露<1 年，OR=1.420；CSA 暴露≥1 年且<5 年，OR=2.240；CSA≥5 年，OR=2.863）。
在这项病例对照研究中，CSA 患者肥胖的风险显著增加。长期暴露于 CSA 和肥胖的可能性更高，且存在剂量-反应关系。
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