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识别长期 1 型和 2 型糖尿病患者的无症状心肌缺血。

Identification of Silent Myocardial Ischemia in Patients with Long-Term Type 1 and Type 2 Diabetes.

机构信息

Department of Internal Medicine, Diabetology and Cardiometabolic Disorders, Faculty of Medical Sciences Zabrze, Medical University of Silesia, 41-800 Zabrze, Poland.

Outpatient Clinic for Patients with Diabetes, 41-800 Zabrze, Poland.

出版信息

Int J Environ Res Public Health. 2022 Jan 27;19(3):1420. doi: 10.3390/ijerph19031420.

Abstract

(1) Background: This study aimed to analyze epidemiological data to identify risk factors for silent myocardial ischemia in patients with long-term type 1 and type 2 diabetes. (2) Methods: An analysis was performed on 104 patients with long-term type 1 and type 2 diabetes who had not previously been diagnosed with cardiovascular disease. During hospitalization, patients were subjected to a standard ECG exercise test on a treadmill. If the test could not be performed or the result was uncertain, a pharmacological exercise test with dobutamine was performed. In the case of a positive exercise ECG test or a positive dobutamine test, the patient underwent coronary angiography. (3) Results: Atherosclerotic lesions were found in 24 patients. Patients with silent ischemia were significantly older and had a lower mean left ventricular ejection fraction and a higher incidence of carotid atherosclerosis. The presence of microvascular complications did not increase the risk of silent ischemia. (4) Conclusions: Silent heart ischemia is more common in type 2 than type 1 diabetes. Predisposing factors include older age, coexistence of carotid atherosclerosis, lower left ventricular ejection fraction, and smoking in patients with type 1 diabetes. Concomitant microvascular complications are not a risk factor.

摘要

(1) 背景:本研究旨在分析流行病学数据,以确定长期 1 型和 2 型糖尿病患者发生无症状心肌缺血的危险因素。(2) 方法:对 104 例长期患有 1 型和 2 型糖尿病但未被诊断为心血管疾病的患者进行了分析。住院期间,患者在跑步机上进行标准心电图运动试验。如果不能进行运动试验或结果不确定,则进行多巴酚丁胺药物运动试验。对于运动心电图阳性或多巴酚丁胺试验阳性的患者,进行冠状动脉造影。(3) 结果:24 例患者发现有动脉粥样硬化病变。无症状缺血患者明显更年长,平均左心室射血分数更低,颈动脉粥样硬化发生率更高。微血管并发症的存在并未增加无症状性心肌缺血的风险。(4) 结论:2 型糖尿病患者比 1 型糖尿病患者更易发生无症状性心肌缺血。易患因素包括年龄较大、伴有颈动脉粥样硬化、左心室射血分数较低以及 1 型糖尿病患者吸烟。合并微血管并发症不是危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e3/8835665/fa80ea433ef8/ijerph-19-01420-g001.jpg

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