Winberg C D, Krance R, Sheibani K, Rappaport H
Cancer. 1986 Jun 15;57(12):2329-42. doi: 10.1002/1097-0142(19860615)57:12<2329::aid-cncr2820571216>3.0.co;2-3.
Peripheral T-cell lymphomas (PTCL) comprise a morphologically heterogeneous group of non-Hodgkin's lymphomas. The authors report on PTCL occurring in a 13-year-old girl, in whom they were able to evaluate histologic material from 11 biopsy specimens obtained during her 8-month clinical course. These biopsy specimens demonstrated morphologic progression from atypical immune reactions and diffuse mixed cell lymphoma observed at different anatomic sites during early stages of the disease to pleomorphic large cell lymphoma with erythrophagocytic tumor cells at the time of her death. Morphologic variability of PTCL that may occur during the course of a patient's illness was demonstrated, and discordant histologic findings in biopsy specimens obtained simultaneously from different anatomic sites was noted. The morphologic evolution of PTCL was expressed, in sequential biopsy specimens, by a progressive cellular pleomorphism with the appearance of large, often bizarre lymphoid cells. This was associated with the gradual diminution and disappearance of the B-cell areas and epithelioid histiocytic reactions which were present initially in the biopsy specimens. The findings suggest that some of the various morphologic descriptions of PTCL given in the literature may represent transient histologic expressions of the lymphoma at various stages in its natural history.
外周T细胞淋巴瘤（PTCL）是一组形态学上异质性的非霍奇金淋巴瘤。作者报告了一名13岁女孩发生的PTCL，在其8个月的临床病程中，作者能够评估从11份活检标本中获取的组织学材料。这些活检标本显示出形态学上的进展，从疾病早期不同解剖部位观察到的非典型免疫反应和弥漫性混合细胞淋巴瘤，发展到她死亡时出现的伴有噬红细胞肿瘤细胞的多形性大细胞淋巴瘤。证实了PTCL在患者病程中可能出现的形态学变异性，并注意到从不同解剖部位同时获取的活检标本中存在不一致的组织学发现。在连续的活检标本中，PTCL的形态学演变表现为细胞逐渐多形性，出现大的、通常形态怪异的淋巴细胞。这与活检标本中最初存在的B细胞区域和上皮样组织细胞反应的逐渐减少和消失有关。这些发现表明，文献中给出的PTCL的各种形态学描述中的一些可能代表了淋巴瘤在其自然病程不同阶段的短暂组织学表现。
