Neurology, The First Hospital of China Medical University, 110001 Shenyang, Liaoning, China.
Neurology, The Fourth Hospital of China Medical University, 110032 Shenyang, Liaoning, China.
J Integr Neurosci. 2022 Jan 28;21(1):9. doi: 10.31083/j.jin2101009.
Epilepsy is one of the most common neurology diseases. It is characterized by recurrent, spontaneous seizures and accompanied by various comorbidities which can significantly affect a person's life. Accumulating evidence indicates an essential pathophysiological role for neuroinflammation in epilepsy, which involves activation of microglia and astrocytes, recruitment of peripheral leukocytes into the central nervous system, and release of some inflammatory mediators, including pro-inflammatory factors and anti-inflammatory cytokines. There is complex crosstalk between the central nervous system and peripheral immune responses associated with the progression of epilepsy. This review provides an update of current knowledge about the contribution of this crosstalk associated with epilepsy. Additionally, how gut microbiota is involved in epilepsy and its possible influence on crosstalk is also discussed. Such recent advances in understanding suggest innovative methods for targeting the molecules correlated with the crosstalk and may provide a better prognosis for patients diagnosed with epilepsy.
癫痫是最常见的神经系统疾病之一。其特征是反复发作的自发性癫痫发作，并伴有各种合并症，这会严重影响一个人的生活。越来越多的证据表明，神经炎症在癫痫中起着重要的病理生理作用，它涉及小胶质细胞和星形胶质细胞的激活、外周白细胞向中枢神经系统的募集，以及一些炎症介质的释放，包括促炎因子和抗炎细胞因子。中枢神经系统与外周免疫反应之间存在与癫痫进展相关的复杂串扰。这篇综述提供了有关这种与癫痫相关的串扰的最新知识。此外，还讨论了肠道微生物群如何参与癫痫及其对串扰的可能影响。对这种串扰的理解的最新进展表明，针对与串扰相关的分子的创新方法可能为诊断患有癫痫的患者提供更好的预后。
