Department of Neurological Surgery The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol. 2021 Nov 16;12:783882. doi: 10.3389/fimmu.2021.783882. eCollection 2021.
It has been reported that several immune cells can release chromatin and granular proteins into extracellular space in response to the stimulation, forming extracellular traps (ETs). The cells involved in the extracellular trap formation are recognized including neutropils, macrophages, basophils, eosinophils, and mast cells. With the development of research related to central nervous system, the role of ETs has been valued in neuroinflammation, blood-brain barrier, and other fields. Meanwhile, it has been found that microglial cells as the resident immune cells of the central nervous system can also release ETs, updating the original understanding. This review aims to clarify the role of the ETs in the central nervous system, especially in neuroinflammation and blood-brain barrier.
据报道，几种免疫细胞在受到刺激时可以将染色质和颗粒蛋白释放到细胞外空间，形成细胞外陷阱（ETs）。涉及细胞外陷阱形成的细胞包括中性粒细胞、巨噬细胞、嗜碱性粒细胞、嗜酸性粒细胞和肥大细胞。随着与中枢神经系统相关研究的发展，细胞外陷阱在神经炎症、血脑屏障等领域的作用受到重视。同时，研究发现中枢神经系统的固有免疫细胞小胶质细胞也可以释放细胞外陷阱，更新了原有的认识。本综述旨在阐明细胞外陷阱在中枢神经系统中的作用，特别是在神经炎症和血脑屏障中的作用。
