Silva Marco Antonio Vieira, Resende Luiz Antonio Pertilli Rodrigues, Vieira Mateus Marchiori, Jajah Camila Blanco Ferreira, Berzotti Lucas Alves, Rambourg Nicole Cristine, de Souza Pierson Ian Dias, Achkar João Lucas Carvalho, Vieira Livia Marchiori, Moreira Guilherme Marchiori, Borges Geisa Ribeiro, Correia Dalmo
Division of Tropical Medicine and Infectious Diseases, Department of Internal Medicine, Federal University of the Triângulo Mineiro, 544 Square, Postal Code, Uberaba, 38025-050, Brazil.
Division of Cardiology, Department of Internal Medicine, Federal University of the Triângulo Mineiro, Uberaba, Brazil.
Clin Hypertens. 2022 Feb 15;28(1):5. doi: 10.1186/s40885-021-00187-x.
Blood pressure variability (BPV) and arterial stiffness show an association with increased cardiovascular events. Evidences demonstrated an association between higher short-term systolic BPV and stiffer arteries. There is no previous study assessed the correlation between BPV and arterial stiffness measured by a Mobil-O-Graph device. We issued to evaluate the correlation between short-term BPV parameters and Mobil-O-Graph pulse wave velocity (PWV) among suspected hypertensive individuals under treatment.
Mobil-O-Graph device estimated arterial stiffness (oscillometric PWV [oPWV]) in 649 individuals, and they recorded 24-h ambulatory BP; 428 had suspected hypertension and 221 under treatment. We analyzed the correlation between oPWV and measures of BPV: SD of 24 h BP (24-h SD), SD of daytime BP (daytime-SD), and SD of nighttime BP (nighttime-SD), weighted SD of 24-h BP (wSD), coefficient of variation of 24-h BP (CV 24-h) and average real variability (ARV).
Oscillometric PWV showed a positive correlation with all systolic BPV measures, in both groups. Among suspected hypertensives: 24-h SD, r = 0.30; SD daytime-SD, r = 0.34; nighttime-SD, r = 0.16; wSD, r = 0.30; CV 24-h, r = 0.24; ARV, r = 0.22. In the treated individuals: 24-h SD, r = 0.46; daytime-SD, r = 0.47; nighttime-SD, r = 0.35; wSD, r = 0.50; CV 24-h, r = 0.43; ARV, r = 0.37, all P < 0.001. Diastolic BPV demonstrated association with some measures of BPV. In suspected hypertensive group: nighttime-SD, r = 0.13; wSD, r = 0.10, both P < 0.001. And in treated individuals: daytime-SD, r = 0.23; wSD, r = 0.22; CV 24-h, r = 0.19 (all P < 0.001), ARV, r = 0.15 (P < 0.05). Systolic daytime-SD in suspected and diastolic CV 24-h in treated group independently predicted oPWV.
We observed a positive and independent correlation between Mobil-O-Graph pulse wave velocity and BPV measures, strong to systolic BPV and weak to diastolic BP.
血压变异性（BPV）与动脉僵硬度和心血管事件增加有关。有证据表明，较高的短期收缩压变异性与动脉僵硬有关。此前尚无研究评估BPV与通过Mobil-O-Graph设备测量的动脉僵硬度之间的相关性。我们旨在评估接受治疗的疑似高血压个体的短期BPV参数与Mobil-O-Graph脉搏波速度（PWV）之间的相关性。
Mobil-O-Graph设备对649名个体的动脉僵硬度（示波PWV [oPWV]）进行了评估，并记录了他们的24小时动态血压；其中428人疑似患有高血压，221人正在接受治疗。我们分析了oPWV与BPV测量指标之间的相关性：24小时血压标准差（24小时SD）、日间血压标准差（日间-SD）、夜间血压标准差（夜间-SD）、24小时血压加权标准差（wSD）、24小时血压变异系数（CV 24小时）和平均实际变异性（ARV）。
在两组中，示波PWV与所有收缩压BPV测量指标均呈正相关。在疑似高血压患者中：24小时SD，r = 0.30；日间-SD，r = 0.34；夜间-SD，r = 0.16；wSD，r = 0.30；CV 24小时，r = 0.24；ARV，r = 0.22。在接受治疗的个体中：24小时SD，r = 0.46；日间-SD，r = 0.47；夜间-SD，r = 0.35；wSD，r = 0.50；CV 24小时，r = 0.43；ARV，r = 0.37，所有P < 0.001。舒张压BPV与某些BPV测量指标有关。在疑似高血压组中：夜间-SD，r = 0.13；wSD，r = 0.10，两者P < 0.001。在接受治疗的个体中：日间-SD，r = 0.23；wSD，r = 0.22；CV 24小时，r = 0.19（所有P < 0.001），ARV，r = 0.15（P < 0.05）。疑似患者的收缩期日间-SD和治疗组的舒张期CV 24小时独立预测oPWV。
我们观察到Mobil-O-Graph脉搏波速度与BPV测量指标之间存在正相关且独立，与收缩压BPV相关性强，与舒张压相关性弱。
