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类风湿关节炎中富集的大颗粒淋巴细胞群体的细胞毒性活性。

Cytotoxic activity of enriched large granular lymphocyte populations in rheumatoid arthritis.

作者信息

Kibler R, Poulos B T, Stanfield A B, Parsons J L

出版信息

Clin Exp Rheumatol. 1986 Jan-Mar;4(1):17-24.

PMID:3516494
Abstract

Enriched large granular lymphocyte (LGL) populations and mononuclear cell populations from peripheral blood of rheumatoid arthritis (RA) patients and control individuals were compared for natural killer (NK) cell activity. The NK activity of the two study groups was very similar when mean values for both cell populations were analyzed. When comparing the difference between the NK activity of the mononuclear cell and LGL populations, 44% of the RA patients demonstrated less of an increase than all of the control individuals although the percentages of LGL, Leu 11+, and Leu 7+ cells were equivalent.

摘要

对类风湿性关节炎(RA)患者和对照个体外周血中富集的大颗粒淋巴细胞(LGL)群体和单核细胞群体的自然杀伤(NK)细胞活性进行了比较。当分析两个细胞群体的平均值时,两个研究组的NK活性非常相似。在比较单核细胞和LGL群体的NK活性差异时,44%的RA患者的增加幅度小于所有对照个体,尽管LGL、Leu 11 +和Leu 7 +细胞的百分比相当。

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