Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R
Clin Exp Rheumatol. 1986 Jan-Mar;4(1):25-9.
In order to study the role of excessive synovial iron sequestration in the production of anemia in rheumatoid arthritis (RA), the antianemic efficacy and anti-inflammatory effect of desferrioxamine administered in a short-term treatment (14 days), were evaluated in 10 patients suffering from classic or definite RA and hyposideremic anemia. Treatment with desferrioxamine showed an elevated urinary iron excretion, a significant increase of serum iron, UIBC and hemoglobin, and a marked progressive decrease of serum ferritin. A moderate improvement of the pain intensity, morning stiffness and Ritchie's index was also observed. The results obtained suggest that excessive reticuloendothelial iron deposits occur in RA and that the iron uptake can be an important factor in the production of anemia. Desferrioxamine seems to be useful in the treatment of patients suffering from RA and anemia, in order to release iron from synovial tissue, reduce the inflammatory process and improve anemia, changing an anemia which is typically resistant to the martial therapy into an iron-sensitive anemia.
为研究滑膜铁过量螯合在类风湿关节炎（RA）贫血产生中的作用，对10例患有典型或确诊RA及低铁血症贫血的患者进行了短期治疗（14天），评估去铁胺的抗贫血疗效和抗炎作用。去铁胺治疗使尿铁排泄增加，血清铁、未饱和铁结合力（UIBC）和血红蛋白显著升高，血清铁蛋白明显逐渐降低。还观察到疼痛强度、晨僵和里奇指数有中度改善。所得结果表明，RA中存在过量的网状内皮铁沉积，铁摄取可能是贫血产生的一个重要因素。去铁胺似乎对治疗患有RA和贫血的患者有用，以便从滑膜组织释放铁，减轻炎症过程并改善贫血，将通常对补充铁剂治疗耐药的贫血转变为铁敏感性贫血。
