Huang W C
Clin Sci (Lond). 1986 May;70(5):453-60. doi: 10.1042/cs0700453.
The effects of verapamil infusion alone and superimposed with captopril on arterial pressure and bilateral renal function were evaluated in 21 two-kidney, one-clip Goldblatt hypertensive rats and in 13 control rats. Verapamil significantly decreased arterial pressure of both hypertensive and control rats. Addition of captopril further reduced arterial pressure in hypertensive rats only. There were significant increases in glomerular filtration rate (GFR), urine flow and absolute and fractional excretory rates of sodium and potassium in the non-clipped kidney. In contrast, these renal indices decreased in the clipped kidney. Superimposed captopril during verapamil infusion did not significantly change function of the non-clipped kidney but further depressed function of the clipped kidney. In control rats, no significant change in GFR occurred in response to drugs. Renal excretion of water and sodium, but not potassium, increased after verapamil. However, the diuresis and natriuresis were less pronounced than those seen in the non-clipped kidney of hypertensive rats. There was a proportionate increase in osmolar clearance and free water reabsorption rate in the non-clipped kidney and the normal kidney. The linear relationship did not change after verapamil infusion. The results suggest that verapamil enhances the excretory function of the non-clipped kidney of Goldblatt hypertensive rats via increased GFR and decreased tubular reabsorption in the proximal and/or distal tubules despite its hypotensive action.
在21只两肾一夹型Goldblatt高血压大鼠和13只对照大鼠中，评估了单独输注维拉帕米以及维拉帕米与卡托普利联合应用对动脉血压和双侧肾功能的影响。维拉帕米显著降低了高血压大鼠和对照大鼠的动脉血压。加用卡托普利仅使高血压大鼠的动脉血压进一步降低。未夹闭肾的肾小球滤过率（GFR）、尿流量以及钠和钾的绝对排泄率和分数排泄率均显著增加。相比之下，夹闭肾的这些肾指标则下降。在输注维拉帕米期间加用卡托普利，未夹闭肾的功能无显著变化，但夹闭肾的功能进一步受损。在对照大鼠中，药物对GFR无显著影响。维拉帕米使水和钠的肾排泄增加，但钾的排泄未增加。然而，利尿和利钠作用不如高血压大鼠未夹闭肾明显。未夹闭肾和正常肾的渗透清除率和自由水重吸收率成比例增加。输注维拉帕米后线性关系未改变。结果表明，尽管维拉帕米有降压作用，但它通过增加GFR以及降低近端和/或远端肾小管的重吸收，增强了Goldblatt高血压大鼠未夹闭肾的排泄功能。
