Tazi Rim, Salimi Zakaria, Fadili Hajar, Aasfara Jehanne, Hazim Asmaa
Neurology, Cheikh Khalifa Ibn Zayed Hospital, Faculty of Medicine, Mohamed VI University of Health Sciences (UM6SS), Casablanca, MAR.
Cureus. 2022 Jan 11;14(1):e21106. doi: 10.7759/cureus.21106. eCollection 2022 Jan.
Neurological paraneoplastic syndromes are a rare entity that affects patients with cancer. Anti-Ri antibodies affect the brain stem and produce a heterogeneous rapidly progressive subacute syndrome depending on the involvement of the different regions concerned. The most common clinical presentation is opsoclonus-myoclonus syndrome and paraneoplastic cerebellar degeneration. Here we report a case of a 60-year-old woman with a subacute static-kinetic cerebellar syndrome, cervical dystonia, and multiple cranial nerve palsies revealing a mammary adenocarcinoma. Anti-Ri antibodies were positive in her blood. Our observation underscored the importance of the identification of the tumor for early treatment management to avoid irreversible neurological manifestations.
神经副肿瘤综合征是一种罕见的疾病，影响癌症患者。抗Ri抗体影响脑干，并根据不同相关区域的受累情况产生异质性快速进展的亚急性综合征。最常见的临床表现是眼阵挛-肌阵挛综合征和副肿瘤性小脑变性。我们在此报告一例60岁女性患者，患有亚急性静动性小脑综合征、颈部肌张力障碍和多发性颅神经麻痹，最终确诊为乳腺腺癌。她血液中的抗Ri抗体呈阳性。我们的观察强调了识别肿瘤对于早期治疗管理的重要性，以避免不可逆的神经表现。
