Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Department of Clinical Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Eur J Nucl Med Mol Imaging. 2022 Jul;49(9):3162-3172. doi: 10.1007/s00259-022-05715-x. Epub 2022 Feb 15.
Chronic traumatic encephalopathy refers to a neurodegenerative disease resulting from repetitive head injury of participants in contact sports. Similar to other neurodegenerative diseases, neuroinflammation is thought to play a role in the onset and progression of the disease. Limited knowledge is available regarding the neuroinflammatory consequences of repetitive head injury in currently active contact sports athletes. PET imaging of the 18-kDa translocator protein (TSPO) allows quantification of microglial activation in vivo, a marker of neuroinflammation.
Eleven rank A kickboxers and 11 age-matched controls underwent TSPO PET using [C]-PK11195, anatomical MRI, diffusion tensor imaging, and neuropsychological testing. Relevant imaging parameters were derived and correlated with the outcomes of the neuropsychological testing.
On a group level, no statistically significant differences were detected in non-displaceable binding potential (BP) using PET. Individually, 3 kickboxers showed increased BPs in widespread regions of the brain without a correlation with other modalities. Increased FA was observed in the superior corona radiata bilaterally. DTI parameters in other regions did not differ between groups.
Despite negative results on a group level, individual results suggest that neuroinflammation may be present as a consequence of repetitive head injury in active kickboxers. Future studies using a longitudinal design may determine whether the observed TSPO upregulation is related to the future development of neuropsychiatric symptoms.
慢性创伤性脑病是一种由参与接触性运动的参与者反复头部受伤引起的神经退行性疾病。与其他神经退行性疾病类似，神经炎症被认为在疾病的发生和进展中起作用。目前关于现役接触性运动运动员反复头部损伤的神经炎症后果的知识有限。18kDa 转位蛋白（TSPO）的 PET 成像可定量活体小胶质细胞激活，这是神经炎症的标志物。
11 名 A 级踢拳运动员和 11 名年龄匹配的对照组使用 [C]-PK11195 进行 TSPO PET、解剖 MRI、扩散张量成像和神经心理学测试。得出相关成像参数，并与神经心理学测试结果相关。
在组水平上，使用 PET 未检测到可置换结合势（BP）的统计学显着差异。个体上，3 名踢拳运动员在大脑广泛区域显示 BP 增加，但与其他方式无关。双侧上辐射冠的 FA 增加。其他区域的 DTI 参数在组间无差异。
尽管在组水平上结果为阴性，但个体结果表明，神经炎症可能是现役踢拳运动员反复头部受伤的后果。使用纵向设计的未来研究可能会确定观察到的 TSPO 上调是否与未来神经精神症状的发展有关。
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