间歇期血浆内皮素-1 水平在发作性和慢性偏头痛患者中没有变化。

Interictal plasma endothelin-1 levels do not change in individuals with episodic and chronic migraine.

机构信息

Department of Neurology, Bio Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.

Laboratory of Immunology, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

出版信息

Cephalalgia. 2022 Jul;42(8):761-768. doi: 10.1177/03331024221075616. Epub 2022 Feb 15.

DOI:10.1177/03331024221075616

PMID:35166151

Abstract

BACKGROUND

Individuals with migraine present ictal elevation of endothelin-1 levels. Migraine can be subclassified into episodic migraine and chronic migraine. Apart from the inconsistent reports on interictal endothelin-1 levels, most studies did not distinguish between episodic migraine and chronic migraine.

METHODS

We measured plasma endothelin-1 levels in participants with episodic migraine (n = 87), with chronic migraine (n = 88), and controls (n = 50).

RESULTS

Interictal endothelin-1 levels were not significantly different among participants with episodic migraine, those with chronic migraine, and controls (pg/ml, median and interquartile range, 10.19 [7.76-13.69] vs. 9.25 [6.91-10.73] vs. 9.46 [7.00-14.19], = 0.131). After excluding participants with fibromyalgia (n = 50) and medication-overuse headache (n = 21), endothelin-1 levels were still similar among groups (10.51 [7.96-14.10] vs. 9.24 [6.96-10.81] vs. 9.46 [7.00-14.19], = 0.230). Endothelin-1 levels did not significantly differ among participants with migraine with aura, those with migraine without aura, and controls (9.36 [4.26-13.35] vs. 9.50 [7.23-13.02] vs. 9.46 [7.00-14.19], = 0.975). There was no significant association of endothelin-1 with headache intensity (mild, 8.99 [8.99-8.99] vs. moderate, 8.71 [6.85-12.15] vs. severe, 9.55 [7.23-13.13], = 0.517) or headache frequency per month (exponential and 95% confidence interval, 0.709 [0.296-1.698], = 0.440) in participants with episodic migraine and chronic migraine.

CONCLUSIONS

Interictal plasma endothelin-1 level is an unlikely marker for episodic migraine and chronic migraine.

摘要

背景

偏头痛患者在发作时有内皮素-1 水平升高。偏头痛可分为发作性偏头痛和慢性偏头痛。除了关于发作间期内皮素-1 水平的不一致报告外，大多数研究并未区分发作性偏头痛和慢性偏头痛。

方法

我们测量了发作性偏头痛患者（n=87）、慢性偏头痛患者（n=88）和对照组（n=50）的血浆内皮素-1 水平。

结果

发作间期内皮素-1 水平在发作性偏头痛患者、慢性偏头痛患者和对照组之间无显著差异（pg/ml，中位数和四分位距，10.19[7.76-13.69]vs.9.25[6.91-10.73]vs.9.46[7.00-14.19]，=0.131）。排除纤维肌痛患者（n=50）和药物过度使用性头痛患者（n=21）后，各组之间的内皮素-1 水平仍相似（10.51[7.96-14.10]vs.9.24[6.96-10.81]vs.9.46[7.00-14.19]，=0.230）。有先兆偏头痛患者、无先兆偏头痛患者和对照组之间的内皮素-1 水平无显著差异（9.36[4.26-13.35]vs.9.50[7.23-13.02]vs.9.46[7.00-14.19]，=0.975）。内皮素-1 与头痛强度（轻度：8.99[8.99-8.99]vs.中度：8.71[6.85-12.15]vs.重度：9.55[7.23-13.13]，=0.517）或每月头痛频率（发作性和 95%置信区间，0.709[0.296-1.698]，=0.440）在发作性偏头痛和慢性偏头痛患者中均无显著相关性。