肥胖程度与血液透析老年患者 SARC-F 的相关性。

Association of Fat Mass with SARC-F in Older Patients Undergoing Haemodialysis.

机构信息

Gustavo Duarte Pimentel, Faculdade de Nutrição, Universidade Federal de Goiás, Rua 227, Quadra 68 s/n°, Setor Leste Universitário, CEP: 74605-080, Goiânia, GO. Brasil. Email:

出版信息

J Nutr Health Aging. 2022;26(2):183-186. doi: 10.1007/s12603-022-1737-4.

DOI:10.1007/s12603-022-1737-4

PMID:35166312

Abstract

BACKGROUND/OBJECTIVES: An increase in fat mass is accompanied by a loss of muscle mass and function in chronic kidney disease. However, no studies in haemodialysis (HD) patients have investigated the relationship between fat mass and sarcopenia. The primary aim of this study is to assess the prevalence of sarcopenia, while the secondary aim is to verify the association between the fat mass percentage and SARC-F and SARC-F combined with calf circumference (SARC-F+CC) in elderly HD patients.

SUBJECTS/METHODS: A cross-sectional study enrolled 96 HD older patients (male, n = 66). SARC-F ≥4 is used to define the muscle function loss, whereas SARC-F ≥6 or SARC-F ≥11 (with the calf circumference added) are the thresholds to diagnose sarcopenia. The fat mass percentage is obtained using bioelectrical impedance analysis.

RESULTS

We found that 37.5% had a risk of muscle function loss due to SARC-F ≥4, 21.8% risk of sarcopenia using the SARC-F ≥6, and when using CC, the prevalence of risk of sarcopenia increased to 41.6% according to SARC-F+CC ≥11. In addition, there was an association between adiposity and sarcopenia for SARC-F ≥6 (OR: 1.25, p= 0.028) and SARC-F+CC ≥11 (OR: 1.25, p= 0.0003), but not with muscle function loss (SARC-F ≥4).

CONCLUSION

In conclusion, we found that 37.5% of HD patients had a risk of muscle function loss and 21-41% presented sarcopenia, depending on the cut-off point used. In addition, higher adiposity was associated with an increased likelihood of having sarcopenia by 25%.

摘要

背景/目的：在慢性肾脏病中，脂肪量增加伴随着肌肉量和功能的丧失。然而，在血液透析（HD）患者中，没有研究调查脂肪量与肌肉减少症之间的关系。本研究的主要目的是评估老年 HD 患者肌肉减少症的患病率，次要目的是验证脂肪量百分比与 SARC-F 和 SARC-F 联合小腿围（SARC-F+CC）在老年 HD 患者中的相关性。

受试者/方法：一项横断面研究纳入了 96 名血液透析老年患者（男性，n=66）。SARC-F≥4 用于定义肌肉功能丧失，而 SARC-F≥6 或 SARC-F≥11（加用小腿围）是诊断肌肉减少症的阈值。脂肪量百分比通过生物电阻抗分析获得。

结果

我们发现，37.5%的患者存在因 SARC-F≥4 导致的肌肉功能丧失风险，21.8%的患者存在 SARC-F≥6 定义的肌肉减少症风险，当使用 CC 时，根据 SARC-F+CC≥11，肌肉减少症风险的患病率增加至 41.6%。此外，在 SARC-F≥6（OR：1.25，p=0.028）和 SARC-F+CC≥11（OR：1.25，p=0.0003）时，肥胖与肌肉减少症之间存在相关性，但与肌肉功能丧失（SARC-F≥4）无关。