Jeffcott L B, Field J R, McLean J G, O'Dea K
Equine Vet J. 1986 Mar;18(2):97-101. doi: 10.1111/j.2042-3306.1986.tb03556.x.
The existence of an innate insulin insensitivity in ponies was investigated and compared with the situation in larger breeds of horse. Ponies that were fat or had previously suffered laminitis were found to be far more intolerant to oral glucose loading (1 g/kg bodyweight [bwt]) than normal ponies or Standardbreds. These ponies also exhibited a far greater response in plasma insulin levels after glucose loading. Insulin response tests (0.4 iu/kg bwt insulin intravenously) showed only a minimal and very protracted response in both the fat and laminitic groups. The relevance of these findings in regulation of carbohydrate and lipid metabolism, and their role in the pathogenesis of hyperlipaemia, are discussed.
研究了矮种马先天性胰岛素不敏感性的存在情况，并与大型马品种的情况进行了比较。发现肥胖或曾患蹄叶炎的矮种马对口服葡萄糖负荷（1克/千克体重）的耐受性远低于正常矮种马或标准赛马。这些矮种马在葡萄糖负荷后血浆胰岛素水平的反应也大得多。胰岛素反应试验（静脉注射0.4国际单位/千克体重胰岛素）显示，肥胖组和蹄叶炎组的反应都非常轻微且持续时间很长。本文讨论了这些发现与碳水化合物和脂质代谢调节的相关性，以及它们在高脂血症发病机制中的作用。
