补充维生素D对老年糖尿病前期患者血糖状态的影响：一项为期12个月的开放标签随机对照研究。

The effect of vitamin D supplementation on glycemic status of elderly people with prediabetes: a 12-month open-label, randomized-controlled study.

作者信息

Zaromytidou Evangelia, Koufakis Theocharis, Dimakopoulos Georgios, Drivakou Despina, Konstantinidou Stavroula, Antonopoulou Vasiliki, Grammatiki Maria, Manthou Eleni, Iakovou Ioannis, Gotzamani-Psarrakou Anna, Kotsa Kalliopi

机构信息

Nuclear Medicine Department, Hippokration General Hospital, Thessaloniki, Greece.

Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Ahepa University Hospital, Thessaloniki, Greece.

出版信息

Expert Rev Clin Pharmacol. 2022 Jan;15(1):89-97. doi: 10.1080/17512433.2022.2043153. Epub 2022 Feb 22.

DOI:10.1080/17512433.2022.2043153

PMID:35167764

Abstract

BACKGROUND

Data on the efficacy of vitamin D in improving the glycemic status of elderly people with prediabetes are scarce. This open-label, randomized-controlled trial investigated the effect of vitamin D supplementation on glycemic markers of Greek people with prediabetes aged 60 years or above, over 12 months.

RESEARCH DESIGN AND METHODS

Participants were randomized to a weekly vitamin D dose of 25,000 IU (n = 45) or nothing (n = 45), on top of lifestyle measures. Anthropometric and glycemic markers were assessed at baseline, 3, 6, and 12 months.

RESULTS

Supplemented participants demonstrated a significant increase in 25(OH)D concentrations at 3, 6, and 12 months compared to baseline . In the intervention group, fasting glucose was decreased at 6 months compared to baseline (96.12 ± 5.51 vs 103.40 ± 12.05 mg/dl, p < 0.01) and glycated hemoglobin was significantly lower at 6 and 12 months compared to baseline [5.82 ± 0.21% vs 5.87 ± 0.21%, p = 0.004 and 5.80 ± 0.23% vs 5.87 ± 0.21%, p < 0.001, respectively].

CONCLUSIONS

Vitamin D could be complementary to lifestyle change strategy for the management of prediabetes in the elderly.

CLINICAL TRIAL REGISTRATION

ISRCTN51643592.

摘要

背景

关于维生素D改善老年糖尿病前期患者血糖状况疗效的数据较少。这项开放标签的随机对照试验研究了补充维生素D对60岁及以上希腊糖尿病前期患者血糖指标的影响，为期12个月。

研究设计与方法

参与者在采取生活方式措施的基础上，被随机分为两组，一组每周服用25,000国际单位的维生素D（n = 45），另一组不服用（n = 45）。在基线、3个月、6个月和12个月时评估人体测量和血糖指标。

结果

与基线相比，补充维生素D的参与者在3个月、6个月和12个月时25(OH)D浓度显著升高。在干预组中，与基线相比，空腹血糖在6个月时降低（96.12±5.51 vs 103.40±12.05mg/dl，p<0.01），糖化血红蛋白在6个月和12个月时显著低于基线[分别为5.82±0.21% vs 5.87±0.21%，p = 0.004；5.80±0.23% vs 5.87±0.21%，p<0.001]。