de Sousa Melo Amanda, Andrade Camila Lima, de Lima Dantas Juliana Borges, Medrado Alena Ribeiro Alves Peixoto, Martins Gabriela Botelho, Lima Hayana Ramos, Carrera Manoela
Department of Life Sciences, State University of Bahia, Rua Silveira Martins 2555, Cabula, Salvador, Bahia, Brazil.
Interactive Processes of Organs and Systems Post Graduation Program, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil.
Support Care Cancer. 2022 Jun;30(6):4897-4904. doi: 10.1007/s00520-022-06899-6. Epub 2022 Feb 15.
To evaluate the impact of photobiomodulation for oral mucositis on body weight and body mass index (BMI) in head and neck cancer patients.
Patients were separated into two groups: photobiomodulation (PBM) (n = 17) and SHAM (n = 19). Participants assigned to the PBM group received the photobiomodulation therapy on alternate days at 33 different sites of the oral mucosa (1 J for 10 s per application point) using a low-power aluminum gallium arsenide (AsGaAl) laser device with a maximum output power of 86.7 mW and a wavelength of 660 nm (red). The same protocol was performed in patients allocated in the SHAM group but with the device turned off. At the first and twenty-fourth radiotherapy sessions, participants from both groups underwent an intraoral examination to assess the presence or absence of mucositis using the WHO scale, and measurements of weight and height for BMI calculation were undertaken.
All patients had significant differences in weight and BMI throughout the study period. Patients in the PBM group lost less weight (p < 0.01) and had a reduced BMI loss (p < 0.01) in comparison to patients in the SHAM group. Although PBM did not prevent oral mucositis, it decreased its severity (p < 0.01).
Photobiomodulation for oral mucositis reduced weight loss and prevented a reduction in BMI in patients who underwent chemoradiotherapy for head and neck cancer. Retrospectively registered at https://data.mendeley.com//datasets/4kd7s49wk4/1 .
评估光生物调节疗法对口腔黏膜炎的治疗效果，以及该疗法对头颈部癌症患者体重和体重指数（BMI）的影响。
将患者分为两组：光生物调节疗法（PBM）组（n = 17）和假治疗组（n = 19）。PBM组的参与者每隔一天接受一次光生物调节治疗，使用最大输出功率为86.7 mW、波长为660 nm（红色）的低功率砷化镓铝（AsGaAl）激光设备，在口腔黏膜的33个不同部位进行照射（每个照射点1 J，照射10 s）。假治疗组的患者接受相同的治疗方案，但设备关闭。在第一次和第二十四次放疗期间，两组参与者均接受口腔检查，使用世界卫生组织（WHO）的标准评估是否存在黏膜炎，并测量体重和身高以计算BMI。
在整个研究期间，所有患者的体重和BMI均有显著差异。与假治疗组相比，PBM组患者体重减轻较少（p < 0.01），BMI下降幅度较小（p < 0.01）。虽然PBM不能预防口腔黏膜炎，但可降低其严重程度（p < 0.01）。
光生物调节疗法可减轻接受头颈部癌症放化疗患者的体重减轻，并防止BMI下降。该研究已在https://data.mendeley.com//datasets/4kd7s49wk4/1上进行回顾性注册。
