Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf 2014, Saudi Arabia.
Curr Drug Saf. 2022;17(4):285-293. doi: 10.2174/1574886317666220216101106.
Individuals suffering from mental illnesses, unfortunately, have a shorter lifespan. An increase in mortality rates is primarily due to physical illness, unhealthy lifestyle, and associated comorbidities. Antipsychotic medications, previously known as tranquilizers, antipsychotics, or neuroleptics, can alleviate or attenuate symptoms related to psychosis, delusion, and/or hallucinations and are used in the treatment of psychosis, schizophrenia, bipolar disorder, depression, or Alzheimer's disease. Within hours to days, these medications alleviate symptoms and reduce confusion in individuals with psychosis; however, the full effect may take longer than usual in some cases. Importantly, these drugs do not cure the disease, but only treat the symptoms of the disease. The treatment is adjusted to reduce any psychotic symptoms while keeping the adverse effects to a minimum level. Antipsychotics may lead to increased risk of diseases, including but not limited to, diabetes, obesity, metabolic disorders, cardiovascular, renal, or respiratory disorders. Improved dosages, polypharmacy, and age-specific treatment play an important role in limiting the comorbidities, as well as the side effects. Further research and clinical attention are required to understand the functioning of these medications. The review focuses on the use of antipsychotic medications in different diseases and their effect on mental health.
患有精神疾病的个体,其寿命往往较短,令人遗憾。死亡率的上升主要归因于躯体疾病、不健康的生活方式以及相关的合并症。抗精神病药物(曾被称为镇静剂、抗精神病药或神经阻滞剂)可以缓解或减轻与精神病、妄想和/或幻觉相关的症状,用于治疗精神病、精神分裂症、双相情感障碍、抑郁症或老年痴呆症。这些药物在数小时至数天内缓解了精神病患者的症状并减轻了其困惑感;但在某些情况下,完全起效可能需要比通常更长的时间。重要的是,这些药物不能治愈疾病,而只能治疗疾病的症状。治疗方案会进行调整,以减少任何精神病症状,同时将不良反应降至最低水平。抗精神病药物可能会增加罹患某些疾病的风险,包括但不限于糖尿病、肥胖症、代谢紊乱、心血管、肾脏或呼吸系统疾病。改善剂量、联合用药和特定年龄的治疗对于限制合并症和副作用起着重要作用。需要进一步的研究和临床关注,以了解这些药物的作用机制。本综述重点介绍了抗精神病药物在不同疾病中的应用及其对精神健康的影响。