Health Sciences University Diskapi Yildirım Beyazit Training and Research Hospital, Dermatology Clinic, Ankara, Turkey; and.
Health Sciences University Diskapi Yildirım Beyazit Training and Research Hospital, Pathology, Ankara, Turkey.
Am J Dermatopathol. 2022 May 1;44(5):380-383. doi: 10.1097/DAD.0000000000002131.
Histiocytoid Sweet syndrome (HSS) is an uncommon histologic variant of Sweet syndrome (SS). HSS can be distinguished from the classic SS with an infiltrate of histiocyte-like immature myeloid cells rather than dense neutrophilic infiltration, although the clinical features are similar. Previous studies have shown that the risk of hematologic malignancy is significantly higher in HSS compared with classic SS. To lesser extent, HSS is also associated with infections, inflammatory diseases, and drugs, particularly with antineoplastic agents as well. Here, we report a case of 2 patients with an abrupt onset of erythematous, tender plaques accompanied by fever, with that revealed similar histopathologic and immunohistochemical features, whom had a history of antibiotic use. Clinicopathologic correlation led to diagnosis of drug-induced HSS, associated with the use of levofloxacin and amoxicillin-clavulanate, respectively. Both patients were then successfully treated with systemic corticosteroid therapy, and neither of them had recurrence during the period of 24-month follow-up.
组织细胞样嗜中性粒细胞皮肤病（HSS）是Sweet 综合征（SS）的一种罕见组织学变异型。虽然临床特征相似，但 HSS 可以通过组织细胞样未成熟髓样细胞浸润而与经典 SS 区分开来，而不是密集的中性粒细胞浸润。先前的研究表明，HSS 发生血液系统恶性肿瘤的风险明显高于经典 SS。在较小程度上，HSS 也与感染、炎症性疾病和药物有关，特别是与抗肿瘤药物有关。在这里，我们报告了 2 例突然出现红斑、触痛斑块伴发热的患者，其具有相似的组织病理学和免疫组织化学特征，且均有抗生素使用史。临床病理相关性导致诊断为药物诱导的 HSS，分别与左氧氟沙星和阿莫西林克拉维酸有关。这 2 例患者均成功接受了全身皮质类固醇治疗，在 24 个月的随访期间均未复发。
