Atkinson K, Norrie S, Chan P, Zehnwirth B, Downs K, Biggs J
Int J Cell Cloning. 1986 May;4(3):203-20. doi: 10.1002/stem.5530040306.
We examined hemopoietic reconstitution during the first 12 months post-transplant in 31 patients given high-dose cyclophosphamide, total body irradiation and an HLA-identical sibling marrow transplant for hematological malignancy. Unexpectedly, we found marrow CFU-gm and marrow CFU-e cells to be denser than normal throughout the first year post-transplant. While functionally adequate neutrophil and platelet counts were achieved in the first six weeks post-transplant, there were defects in hemopoietic progenitor cell function during the first year post-transplant. Although we could detect no influence from acute graft-versus-host disease (GVHD), chronic GVHD adversely affected the growth of both myeloid and erythroid blood progenitor cells.
我们对31例因血液系统恶性肿瘤接受大剂量环磷酰胺、全身照射及 HLA 同型同胞骨髓移植的患者在移植后的前12个月内的造血重建情况进行了检查。出乎意料的是，我们发现移植后的第一年里，骨髓粒系集落形成单位（CFU-gm）和骨髓红系集落形成单位（CFU-e）细胞比正常情况更为密集。虽然在移植后的前六周中性粒细胞和血小板计数在功能上达到了足够水平，但在移植后的第一年里造血祖细胞功能存在缺陷。尽管我们未检测到急性移植物抗宿主病（GVHD）的影响，但慢性 GVHD 对髓系和红系造血祖细胞的生长均产生了不利影响。
