Lages Yury V, Maisonnette Silvia S, Rosseti Flávia P, Krahe Thomas E, Landeira-Fernandez J
Department of Psychology, Núcleo de Neuropsicologia Clínica e Experimental, Laboratório de Neurociência Comportamental, Pontifical Catholic University of Rio de Janeiro, 225, Rua Marquês de São Vicente, Rio de Janeiro, RJ 22453-900, Brazil.
Department of Psychology, Núcleo de Neuropsicologia Clínica e Experimental, Laboratório de Neurociência Comportamental, Pontifical Catholic University of Rio de Janeiro, 225, Rua Marquês de São Vicente, Rio de Janeiro, RJ 22453-900, Brazil.
Physiol Behav. 2022 May 1;248:113742. doi: 10.1016/j.physbeh.2022.113742. Epub 2022 Feb 13.
Stress and eating disorders are closely related and are a topic of major concern due to their burden on human health. Engaging in unhealthy eating habits may come as a result of stress, and it often serves to alleviate the symptoms of anxiety or as a distraction from the stressor itself or self-awareness. However, it can also lead to negative feelings of a person's body figure, guilty, or shame. As diverse as these consequences are in humans, so are the effects of the combined administration of stress and hypercaloric food in animals' models. In this study, we assessed the influence of individual innate behavioral predisposition on the effects of chronic unpredictable mild stress and the dietary supplementation with high-sugar/high-fat food. These conditions were applied to male Carioca low- and high-conditioned freezing (CLF and CHF) rats for 21 days. Behavioral results show that the hypercaloric supplement had a protective effect over the alterations caused by the stress. Notably, it was more strongly observed in CHF rather than CLF animals. As the chronic stress led to an impaired behavior in the contextual fear conditioning and the forced swimming tests in the CLF line, animals fed with the HSHF pellet scored responses similar to their untreated control. On CHF rats, these effects also were seen to a broader extent on the open field test, where the locomotor behavior was also increased. No major effects of the diet were seen in the unstressed groups. Overall, our results show that the influences of both chronic stress and hypercaloric feeding depend on innate differences in fear response traits of male Carioca rats.
压力与饮食失调密切相关，由于它们对人类健康造成负担，因此是一个备受关注的话题。不健康的饮食习惯可能是压力导致的结果，它常常有助于缓解焦虑症状，或者分散对压力源本身或自我意识的注意力。然而，它也可能导致一个人对自己身材产生负面情绪、内疚或羞耻感。这些后果在人类中多种多样，在动物模型中，压力与高热量食物联合施用的影响也是如此。在本研究中，我们评估了个体先天行为倾向对慢性不可预测轻度应激以及高糖/高脂肪食物饮食补充效果的影响。将这些条件应用于雄性里约热内卢低条件化和高条件化冷冻（CLF和CHF）大鼠21天。行为结果表明，高热量补充剂对压力引起的改变具有保护作用。值得注意的是，在CHF动物中比在CLF动物中观察到的效果更强。由于慢性应激导致CLF品系在情境恐惧条件反射和强迫游泳试验中的行为受损，喂食HSHF颗粒的动物的反应与未处理的对照组相似。在CHF大鼠中，在旷场试验中也更广泛地观察到这些影响，在该试验中运动行为也增加了。在无应激组中未观察到饮食的主要影响。总体而言，我们的结果表明，慢性应激和高热量喂养的影响都取决于雄性里约热内卢大鼠恐惧反应特征的先天差异。
