Guo Xiangcen, Liu Li, Wang Junling, Chen Lei, Sang Jianzhong, Cao Hua, Chen Ying
Department of Otorhinolaryngology Head and Neck Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450052,China.
Department of Medicine,Henan Medical College.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Feb;36(2):125-129. doi: 10.13201/j.issn.2096-7993.2022.02.010.
The aim of this study is to investigate the pathological features, treatment and prognosis of sarcomatoid carcinoma of head and neck. The clinical data of 17 patients with sarcomatoid carcinoma of the head and neck treated in the First Affiliated Hospital of Zhengzhou University from September 2013 to September 2020 were retrospectively analyzed, and the pathological characteristics, treatment and follow-up were summarized. Kaplan-Meier method was used to calculate the overall survival rate. The histopathological examination of all patients showed the coexistence of cancer components and sarcoma components, and there was a transitional transition area between them. In terms of treatment, 12 of the 17 patients received surgical treatment, and 5 patients received palliative treatment because they could not tolerate surgery or distant metastasis; The cumulative 1-year, 3-year and 5-year survival rates of 17 patients with head and neck sarcomatoid carcinoma calculated by Kaplan-Meier method were 64.7%, 26.5%, and 13.2%, respectively. Pathological examination of head and neck sarcomatoid carcinoma is the gold standard for diagnosis. Radical surgery is the first choice for treatment. It has a high degree of malignancy and poor prognosis. Early diagnosis and radical surgery can improve the survival rate of patients to a certain extent.
本研究旨在探讨头颈部肉瘤样癌的病理特征、治疗方法及预后。回顾性分析2013年9月至2020年9月在郑州大学第一附属医院接受治疗的17例头颈部肉瘤样癌患者的临床资料,总结其病理特征、治疗情况及随访结果。采用Kaplan-Meier法计算总生存率。所有患者的组织病理学检查均显示癌成分与肉瘤成分并存,且二者之间存在移行过渡区。治疗方面,17例患者中12例接受了手术治疗,5例因无法耐受手术或发生远处转移而接受了姑息治疗;采用Kaplan-Meier法计算的17例头颈部肉瘤样癌患者的1年、3年和5年累积生存率分别为64.7%、26.5%和13.2%。头颈部肉瘤样癌的病理检查是诊断的金标准。根治性手术是治疗的首选。其恶性程度高,预后差。早期诊断及根治性手术可在一定程度上提高患者的生存率。