Guo Rui, Aizezi Aihaiti, Fan Yong, Ji Zhe, Li Wenzong, Li Yongxian, Wang Zhigang, Ning Kai
Department of Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China.
Department of Surgery, People's Hospital of Burqin County, Altay, 836500, Xinjiang, China.
BMC Sports Sci Med Rehabil. 2022 Feb 16;14(1):26. doi: 10.1186/s13102-022-00421-5.
Tendon-ligament injuries (TLIs), including Achilles tendinopathy, cruciate ligament injury, tennis elbow, rotator cuff injury, patellar tendinopathy, and tibial tendinopathy, are common musculoskeletal soft injuries during physical activity. Matrix metalloproteinase-3 (MMP-3) gene polymorphisms have been implicated in the etiology of TLIs in several genetic association studies with inconsistent results. The purpose of this study was to collect and synthesize the current evidences on the association of MMP-3 polymorphisms and TLIs.
The search was conducted using PubMed, Web of Science, EMBASE, Cochrane Library, CNKI and Wanfang databases, prior to July, 2021. Newcastle Ottawa Scale was used to appraise the study quality. Strengths of association were represented by odds ratios (ORs) and 95% confidence intervals (95% CIs).
Thirteen studies with 2871 cases and 4497 controls met the eligibility criteria, and each study was in high quality. The overall analyzes suggested rs3025058 was associated with an increased TLIs risk (5A vs. 6A, OR = 1.20, 95% CI 1.03-1.40, P = 0.020). However, the association was not found for rs679620, rs591058, and rs650108 polymorphisms. Subgroup analysis by injury type suggested that rs679620 polymorphism was associated with a reduced risk to Achilles tendon rupture (AA + AG vs. GG, OR = 0.46, 95% CI 0.25-0.87, P = 0.020), and rs3025058 was associated with an elevated risk to anterior cruciate ligament injury (5A5A + 5A6A vs. 6A6A, OR = 1.46, 95% CI 1.03-2.06, P = 0.030). When stratified by ethnicity, the findings indicated that rs3025058 polymorphism was associated with an increased TLIs risk among Caucasians (5A6A vs. 6A6A, OR = 1.55, 95% CI 1.09-2.42, P = 0.020) and Brazilians (5A5A vs. 5A6A + 6A6A, OR = 2.80, 95% CI 1.44-5.45, P = 0.002).
Findings of this study suggest that rs679620 polymorphism is associated with a reduced Achilles tendon rupture risk, and rs3025058 polymorphism contributes to an increased TLIs risk in Caucasians and Brazilians. However, rs591058 and rs650108 polymorphisms do not show any association with TLIs.
肌腱韧带损伤（TLIs），包括跟腱病、十字韧带损伤、网球肘、肩袖损伤、髌腱病和胫腱病，是体育活动中常见的肌肉骨骼软组织损伤。在多项遗传关联研究中，基质金属蛋白酶-3（MMP-3）基因多态性与肌腱韧带损伤的病因有关，但结果并不一致。本研究的目的是收集和综合目前关于MMP-3多态性与肌腱韧带损伤关联的证据。
于2021年7月之前，使用PubMed、Web of Science、EMBASE、Cochrane图书馆、中国知网和万方数据库进行检索。采用纽卡斯尔渥太华量表评估研究质量。关联强度用比值比（ORs）和95%置信区间（95% CIs）表示。
13项研究，共2871例病例和4497例对照符合纳入标准，每项研究质量均较高。总体分析表明，rs3025058与肌腱韧带损伤风险增加相关（5A vs. 6A，OR = 1.20，95% CI 1.03 - 1.40，P = 0.020）。然而，未发现rs679620、rs591058和rs650108多态性与肌腱韧带损伤有关联。按损伤类型进行亚组分析表明，rs679620多态性与跟腱断裂风险降低相关（AA + AG vs. GG，OR = 0.46，95% CI 0.25 - 0.87，P = 0.020），rs3025058与前交叉韧带损伤风险升高相关（5A5A + 5A6A vs. 6A6A，OR = 1.46，95% CI 1.03 - 2.06，P = 0.030）。按种族分层时，研究结果表明，rs3025058多态性与白种人（5A6A vs. 6A6A，OR = 1.55，95% CI 1.09 - 2.42，P = 0.020）和巴西人（5A5A vs. 5A6A + 6A6A，OR = 2.80，95% CI 1.44 - 5.45，P = 0.002）的肌腱韧带损伤风险增加相关。
本研究结果表明，rs679620多态性与跟腱断裂风险降低相关，rs3025058多态性与白种人和巴西人的肌腱韧带损伤风险增加相关。然而，rs591058和rs650108多态性与肌腱韧带损伤无任何关联。
