金属蛋白酶在疼痛产生和持续中的作用：可能的靶点？

Operative Unit of Pharmacology and Pharmacovigilance, "Mater Domini" University Hospital, 88100 Catanzaro, Italy.

Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy.

Biomolecules. 2023 Jan 31;13(2):268. doi: 10.3390/biom13020268.

Matrix metalloproteinases (MMPs) are a large family of zinc-dependent proteolytic enzymes associated with extracellular matrix protein turnover and tissue degradation. They participate to many different physiological reactions but are also hyperactivated in several diseases. Various literature studies have documented that MMPs play a role in the modulation of neuropathic and nociceptive pain. The heterogeneity of clinical and pre-clinical data is an important issue in this experimental context. Despite the presence of a good number of studies on MMP inhibitors, these drugs showed scarce efficacy and relevant side effects. In the present manuscript, we reviewed studies in the literature that define a possible role of MMPs in pain and the effects of their modulation.

基质金属蛋白酶（MMPs）是一大类锌依赖性蛋白水解酶，与细胞外基质蛋白的代谢和组织降解有关。它们参与许多不同的生理反应，但在多种疾病中也被过度激活。许多文献研究表明 MMPs 在神经病理性和伤害性疼痛的调节中发挥作用。在这种实验背景下，临床和临床前数据的异质性是一个重要问题。尽管有许多关于 MMP 抑制剂的研究，但这些药物的疗效和相关副作用都很少。在本文中，我们回顾了文献中的研究，这些研究定义了 MMPs 在疼痛中的可能作用及其调节作用。