Jin Xiaochun, Zhang Ying, Wang Hui, Zhang Youtao
Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, Jiangsu, People's Republic of China.
Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Int J Gen Med. 2022 Feb 10;15:1393-1403. doi: 10.2147/IJGM.S344345. eCollection 2022.
To investigate the expression of serum miR-155 and miR-224 among patients with hepatitis C virus (HCV) infection and analyze their clinical values.
A total of 116 patients suffering from HCV infection admitted to our hospital and 70 healthy subjects were selected. According to the diagnostic results, patients with HCV infection were divided into 48 cases of chronic hepatitis C (CHC), 43 cases of liver cirrhosis and 25 cases of hepatocellular carcinoma (HCC). The expression signature for miR-155 and miR-224 was detected in serum samples. ROC curve and Pearson correlation test were conducted to investigate their diagnostic value and correlation.
The expression extent for serum miR-155 and miR-224 increased along with the increase of malignancy (all P < 0.05). According to ROC curve, the area under the curve (0.918, 95% CI: 0.856-0.974) of miR-155 and miR-224 combined in the diagnosis of HCC was the largest, and its sensitivity and specificity were 93.0% and 86.2%. There is a positive relationship for expression level between miR-155 and miR-224 in CHC and HCC group (all P < 0.001).
miR-155 and miR-224 are remarkably increased in patients suffering from HCV infection. The combination of miR-155 and miR-224 has a good diagnostic value for HCC caused by HCV infection.
探讨丙型肝炎病毒（HCV）感染患者血清miR-155和miR-224的表达情况，并分析其临床价值。
选取我院收治的116例HCV感染患者及70例健康对照者。根据诊断结果，将HCV感染患者分为慢性丙型肝炎（CHC）48例、肝硬化43例和肝细胞癌（HCC）25例。检测血清样本中miR-155和miR-224的表达特征。采用ROC曲线和Pearson相关性检验来研究其诊断价值及相关性。
血清miR-155和miR-224的表达水平随恶性程度增加而升高（均P < 0.05）。根据ROC曲线，miR-155和miR-224联合诊断HCC时曲线下面积最大（0.918，95%CI：0.856 - 0.974），其敏感性和特异性分别为93.0%和86.2%。CHC组和HCC组中miR-155与miR-224的表达水平呈正相关（均P < 0.001）。
HCV感染患者中miR-155和miR-224显著升高。miR-155和miR-224联合检测对HCV感染所致HCC具有良好的诊断价值。
