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一名慢性粒细胞白血病患者发生沙雷氏菌性心内膜炎的有趣病例。

An Interesting Case of Serratia Endocarditis in a Patient With Chronic Myeloid Leukemia.

作者信息

Singh Annapoorna, Tappeta Kathyayini, Chellapuram Nikitha, Singh Daulath

机构信息

Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.

Internal Medicine, St. George's University School of Medicine, True Blue, GRD.

出版信息

Cureus. 2022 Jan 14;14(1):e21238. doi: 10.7759/cureus.21238. eCollection 2022 Jan.

Abstract

is a rare cause of infective endocarditis (IE) and usually occurs in patients with underlying risk factors, such as intravenous (IV) drug use, and human immunodeficiency virus patients. Gram-negative bacteria endocarditis is associated with high mortality when it involves the left side of the heart and often requires surgical intervention in addition to medical treatment. Although most gram-negative endocarditis cases are hospital-acquired, community cases have also been reported. Here, we present a case of endocarditis in an individual who was later diagnosed with chronic myeloid leukemia (CML) during the same hospitalization. The patient was treated with IV meropenem and started on targeted therapy for CML. CML is presumed to have likely predisposed the patient to bacteremia and IE.

摘要

是感染性心内膜炎(IE)的罕见病因,通常发生在有潜在危险因素的患者中,如静脉注射(IV)吸毒者以及人类免疫缺陷病毒患者。革兰氏阴性菌心内膜炎累及心脏左侧时死亡率较高,除药物治疗外通常还需要手术干预。虽然大多数革兰氏阴性菌心内膜炎病例是医院获得性的,但也有社区病例的报道。在此,我们报告一例心内膜炎病例,该患者在同一住院期间后来被诊断为慢性髓性白血病(CML)。患者接受了静脉注射美罗培南治疗,并开始了针对CML的靶向治疗。据推测,CML可能使该患者易发生菌血症和IE。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2434/8841042/5b9e7d237012/cureus-0014-00000021238-i01.jpg

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