Otorhinolaryngology Department, Başkent University Medical Faculty, Ankara, Turkey.
Dermatology Department, Başkent University Medical Faculty, Ankara, Turkey.
J Cosmet Dermatol. 2022 May;21(5):1788-1795. doi: 10.1111/jocd.14855. Epub 2022 Feb 28.
The new severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the causative agent of coronavirus 2019 (COVID-2019) disease. A wide variety of symptoms of the disease has been frequently reported in the literature in recent years. However, information on the findings in keratinized tissues is still limited. Data on changes in keratinized tissues such as nails, teeth and hair, and oral mucousa due to drugs used in the treatment of this disease are also extremely insufficient.
With this study, it was aimed to evaluate the changes in the keratinized tissues of our patients with COVID-19, who are frequently encountered in the Ear Nose and Throat outpatient clinic.
The study was carried out on patients who applied to Başkent University Ear Nose and Throat clinic. There were 3 groups. The first group consisted of patients diagnosed with COVID-19 and received relevant medical treatments, the second group included individuals who have never experienced COVID-19 infection but have been vaccinated against COVID-19, and the third group is the control group with normal healthy individuals who have never been diagnosed with COVID-19 infection and have not been vaccinated so far. With the Wood's lamp, fluorescent changes in nails, hair, tooth, and the oral mucousa were recorded.
A total of 124(75 females, 49 males) patients were included in the study. Positive Wood's finding was significantly higher in COVID-19 group(Group 1) who received Favipravir when compared with individuals who did not receive Favipravir (p < 0.001). Wood's positivity was not detected in any of the individuals who did not use favipravir. The rate of determining Wood's positivity in favipravir users decreases after 58 days.
Accordingly, Favipravir accumulation in the kretainized tissues manifest positive Wood's sign in our study.
The adverse effects of the accumulation of the drugs-mainly Favipravir-used in the treatment of COVID-19 disease, have not yet been clearly demonstrated so far. Revealing the findings in these tissues with this study will pave the way for investigating changes or drug sequestrations in other organs in the long term.
新型严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是导致 2019 年冠状病毒病（COVID-19）的病原体。近年来，文献中频繁报道了该病的各种症状。然而，关于角化组织的发现信息仍然有限。关于指甲、牙齿和毛发等角化组织以及口腔黏膜因治疗这种疾病而发生变化的信息也极其不足。
通过这项研究，我们旨在评估在耳鼻喉科门诊经常遇到的 COVID-19 患者的角化组织变化。
该研究是在就诊于巴肯特大学耳鼻喉科诊所的患者中进行的。有 3 组。第一组由诊断为 COVID-19 并接受相关治疗的患者组成，第二组包括从未感染过 COVID-19 但已接种 COVID-19 疫苗的个体，第三组是对照组，由从未被诊断为 COVID-19 感染且目前尚未接种疫苗的健康个体组成。用伍德灯记录指甲、毛发、牙齿和口腔黏膜的荧光变化。
共有 124 名（75 名女性，49 名男性）患者纳入研究。与未使用法匹拉韦的患者相比，接受法匹拉韦治疗的 COVID-19 组（第 1 组）的阳性伍德发现率明显更高（p<0.001）。未使用法匹拉韦的个体未检测到伍德阳性。使用法匹拉韦的个体在 58 天后，确定伍德阳性的比率降低。
因此，在我们的研究中，法匹拉韦在角化组织中的积累表现出阳性伍德信号。
迄今为止，COVID-19 治疗中使用的药物（主要是法匹拉韦）积累的不良反应尚未得到明确证实。通过这项研究揭示这些组织中的发现将为长期研究其他器官的变化或药物隔离铺平道路。
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