Ponce-de-León Jaime, Marcos-Ayuso Guillermo, Casares Juan A, Espinet Pablo
IU CINQUIMA/Química Inorgánica, Facultad de Ciencias, Universidad de Valladolid, Valladolid-47071, Spain.
Chem Commun (Camb). 2022 Mar 3;58(19):3146-3149. doi: 10.1039/d2cc00141a.
An efficient Pd/Cu bimetallic cross-coupling catalysis of fluoroaryl halides and fluoroarenes is reported. generation of the Cu nucleophile by rate determining C-H activation of highly fluorinated aryls (≥4 F atoms) leads to high cross-coupling selectivity with little formation of homocoupling products.
据报道，氟代芳基卤化物和氟代芳烃可实现高效的钯/铜双金属交叉偶联催化。通过对高度氟化的芳基（≥4个氟原子）进行速率决定步骤的C-H活化生成铜亲核试剂，可实现高交叉偶联选择性，且几乎不生成均偶联产物。
