桥粒斑蛋白将二者（皮质肌动蛋白和中间丝细胞骨架）联系在一起。
Plectin pulls it together, coupling the cortical actin and intermediate filament cytoskeletons.
机构信息
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
出版信息
J Cell Biol. 2022 Mar 7;221(3). doi: 10.1083/jcb.202201054. Epub 2022 Feb 17.
The integration of cytoskeletal/adhesive networks is critical to epithelial mechanobiology. In this issue, Prechova et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202105146) demonstrate that the cytolinker protein plectin is essential for the construction of a cortical cytoskeletal architecture required for epithelial tensional homeostasis.
细胞骨架/黏附网络的整合对于上皮细胞的机械生物学至关重要。在本期杂志中，Prechova 等人（2022.《细胞生物学杂志》https://doi.org/10.1083/jcb.202105146）表明，细胞连接蛋白 plectin 对于构建上皮细胞张力平衡所需的皮质细胞骨架结构是必不可少的。
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