超短波透热疗法对脂多糖诱导的大鼠肺损伤的抗炎抗氧化作用。
Anti-Inflammatory and Anti-Oxidant Activity of Ultra-Short Wave Diathermy on LPS-Induced Rat Lung Injury.
机构信息
The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
The First Affiliated Hospital of University of South China, Department of Rehabilitation, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
出版信息
Bull Exp Biol Med. 2022 Feb;172(4):423-429. doi: 10.1007/s10517-022-05407-4. Epub 2022 Feb 17.
We studied the lung-protective effect and mechanisms of the anti-inflammatory and antioxidant effects of ultra-short-wave diathermy (USWD) in a rat model of LPS-induced acute lung injury. Histological examination of the lung tissues was performed and the levels of oxidative stress-related factors and inflammatory cytokines were measured. It was shown that the lung injury score, the lung wet-to-dry weight ratio (W/D), oxidative stress-related factors malondialdehyde and acyl-CoA synthetase long-chain family member 4 (ACSL4), and inflammatory cytokines were increased after LPS administration, while USWD treatment reduced these parameters. In addition, superoxide dismutase and glutathione peroxidase 4 were decreased in rats with LPS-induced acute lung injury, while USWD therapy up-regulated the expression of these enzymes. Thus, USWD could antagonize lung injury by inhibiting oxidative stress and inflammatory response in rats with acute lung injury. USWD can be a promising adjunctive treatment to counter oxidative stress and inflammation and a potential therapeutic candidate for the treatment of patients with this pathology.
我们研究了超短波透热疗法（USWD）在脂多糖诱导的急性肺损伤大鼠模型中的抗炎和抗氧化作用的肺保护作用及其机制。对肺组织进行组织学检查，并测量氧化应激相关因子和炎症细胞因子的水平。结果表明，LPS 给药后肺损伤评分、肺湿重/干重比（W/D）、氧化应激相关因子丙二醛和酰基辅酶 A 合成酶长链家族成员 4（ACSL4）以及炎症细胞因子增加，而 USWD 治疗降低了这些参数。此外，LPS 诱导的急性肺损伤大鼠中超氧化物歧化酶和谷胱甘肽过氧化物酶 4 减少，而 USWD 治疗上调了这些酶的表达。因此，USWD 可通过抑制急性肺损伤大鼠的氧化应激和炎症反应来拮抗肺损伤。USWD 可能是对抗氧化应激和炎症的一种有前途的辅助治疗方法，也是治疗这种病理患者的潜在治疗候选药物。
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