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Targeting GPVI with glenzocimab in COVID-19 patients: Results from a randomized clinical trial.以 glenzocimab 靶向 GPVI 在 COVID-19 患者中的应用：一项随机临床试验结果。
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Platelet aggregates detected using quantitative phase imaging associate with COVID-19 severity.使用定量相成像检测到的血小板聚集体与新冠肺炎严重程度相关。
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Antiplatelet therapy for patients with COVID-19: Systematic review and meta-analysis of observational studies and randomized controlled trials.2019冠状病毒病患者的抗血小板治疗：观察性研究和随机对照试验的系统评价与荟萃分析
Front Med (Lausanne). 2022 Sep 7;9:965790. doi: 10.3389/fmed.2022.965790. eCollection 2022.

本文引用的文献

1
Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity.血小板和巨核细胞在固有和适应性免疫中的作用。
Circ Res. 2022 Jan 21;130(2):288-308. doi: 10.1161/CIRCRESAHA.121.319821. Epub 2022 Jan 20.
2
Antiplatelet Therapy in Patients With COVID-19-More Is Less?新冠病毒肺炎患者的抗血小板治疗——多即少？
JAMA. 2022 Jan 18;327(3):223-224. doi: 10.1001/jama.2021.23866.
3
Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.非危重症 COVID-19 住院患者中 P2Y12 抑制剂对无器官支持生存的影响：一项随机临床试验。
JAMA. 2022 Jan 18;327(3):227-236. doi: 10.1001/jama.2021.23605.
4
Bleeding Risk of Dual Antiplatelet Therapy after Minor Stroke or Transient Ischemic Attack.轻型卒中和短暂性脑缺血发作后双联抗血小板治疗的出血风险。
Ann Neurol. 2022 Mar;91(3):380-388. doi: 10.1002/ana.26287. Epub 2022 Jan 10.
5
Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19.基于海量图像的单细胞分析揭示 COVID-19 患者循环血小板聚集物水平较高。
Nat Commun. 2021 Dec 9;12(1):7135. doi: 10.1038/s41467-021-27378-2.
6
Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.COVID-19 患者住院期间使用阿司匹林（RECOVERY）：一项随机、对照、开放标签、平台试验。
Lancet. 2022 Jan 8;399(10320):143-151. doi: 10.1016/S0140-6736(21)01825-0. Epub 2021 Nov 17.
7
Platelets contribute to disease severity in COVID-19.血小板与 COVID-19 的疾病严重程度有关。
J Thromb Haemost. 2021 Dec;19(12):3139-3153. doi: 10.1111/jth.15534. Epub 2021 Sep 29.
8
Platelets amplify endotheliopathy in COVID-19.血小板会加剧新冠病毒肺炎中的内皮病变。
Sci Adv. 2021 Sep 10;7(37):eabh2434. doi: 10.1126/sciadv.abh2434. Epub 2021 Sep 8.
9
Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID-19: A propensity score-matched analysis.COVID-19 住院患者中院前抗血小板治疗与生存的关系：倾向评分匹配分析。
J Thromb Haemost. 2021 Nov;19(11):2814-2824. doi: 10.1111/jth.15517. Epub 2021 Sep 15.
10
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.新冠肺炎危重症患者的肝素治疗性抗凝。
N Engl J Med. 2021 Aug 26;385(9):777-789. doi: 10.1056/NEJMoa2103417. Epub 2021 Aug 4.

Shining a light on platelet activation in COVID-19.

作者信息

Denorme Frederik, Ajanel Abigail, Campbell Robert A

机构信息

University of Utah Molecular Medicine Program, Salt Lake City, Utah, USA.

Department Pathology, Division of Microbiology and Pathology, University of Utah, Salt Lake City, Utah, USA.

出版信息

J Thromb Haemost. 2022 Jun;20(6):1286-1289. doi: 10.1111/jth.15678. Epub 2022 Mar 2.

DOI:10.1111/jth.15678
PMID:35175688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9115194/
Abstract
摘要