Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, India.
Centre for Infectious Disease, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal 576104, India.
Curr Protein Pept Sci. 2022;23(2):105-113. doi: 10.2174/1389203723666220217144432.
The life cycle of the Herpes simplex virus starts with attachment to the host cell, injection of the nucleocapsid into the cytoplasm, replication, transcription and viral protein production, and finally, the assembly of the mature virion nucleopcapsid. The assembled nucleocapsid exits the host nucleus and gains a tegument layer bound within a bilayer of membrane phospholipid. The packaged virion particle then exits the host cell. The interaction of the (Deoxyribonucleic acid) DNA packaging complex- terminase, present on the mature viral nucleocapsid, with other proteins involved in nuclear egress and cytoplasmic tegumentation has led to the proposal of the model by which the terminase complex may be involved in these two events. The role of terminase complex in Herpes Simplex Virus (HSV) genomic DNA encapsidation into the capsid is previously established, but the role of the terminase subunits post DNA packaging remains unclear. The current review provides a model by which the terminase complex may have a role to play in the events of nuclear egress and secondary envelopment.
单纯疱疹病毒的生命周期始于与宿主细胞的附着、核衣壳注入细胞质、复制、转录和病毒蛋白的产生，最后是成熟病毒核衣壳的组装。组装好的核衣壳离开宿主细胞核，并获得一层包裹在双层膜磷脂中的被膜。然后，包装好的病毒颗粒离开宿主细胞。(脱氧核糖核酸)DNA 包装复合物-末端酶与其他参与核出芽和细胞质被膜化的蛋白质的相互作用，导致了提出的模型，其中末端酶复合物可能参与这两个事件。末端酶复合物在单纯疱疹病毒(HSV)基因组 DNA 包装到衣壳中的作用以前已经确定，但 DNA 包装后末端酶亚基的作用仍不清楚。目前的综述提供了一个模型，其中末端酶复合物可能在核出芽和二次包裹的事件中发挥作用。
