Department of Medicine, Emory University, Atlanta, Georgia, USA
Department of Epidemiology, Emory University, Atlanta, Georgia, USA.
Lupus Sci Med. 2022 Feb;9(1). doi: 10.1136/lupus-2022-000658.
To examine whether pandemic-related issues were associated with physical functioning, community mobility and cognition among individuals with SLE.
Participants were recruited (6 October 2020-11 November 2021) for this cross-sectional study from a population-based cohort of individuals with validated SLE in metropolitan Atlanta, as part of an ongoing ancillary study. Pandemic-related issues (concern about the pandemic (very vs somewhat/not at all concerned); changes in physical activity and sleep (less vs more/same); difficulty obtaining food and medications and accessing routine care (any vs none)) were self-reported. Self-reported physical functioning and episodic and working memory performance were reported as t-scores (such that a score of 50=population mean and a 10-point difference=1 SD) and community mobility scores ranged from 0 to 120, with higher scores representing better functioning for all domains. Differences in scores were assessed via t-tests and age-adjusted, sex-adjusted and race-adjusted linear regression.
Among 245 participants (mean age, 46 years; 95% female, 77% black), physical functioning t-scores (mean=44) were consistently lower (by 3-5 points) for those who reported concern about the pandemic, less physical activity and sleep, difficulty obtaining food and medications, and accessing routine care. Similarly, community mobility scores (mean=48) were lower (by 10-20 points) for these individuals. There were no substantial differences in episodic memory and working memory t-scores (mean=50 and 47, respectively) by pandemic-related issues.
We found that physical functioning and community mobility, but not cognition, were lower among those who reported more concern about the pandemic or greater disruptions to health routines. Future studies should explore interventions among these vulnerable individuals with SLE, who already disproportionately suffer from functional impairment, to maintain functioning and prevent adverse outcomes during times of crisis.
探讨大流行相关问题是否与 SLE 患者的身体机能、社区活动能力和认知能力有关。
这项横断面研究从亚特兰大都会区基于人群的 SLE 患者队列中招募了参与者（2020 年 10 月 6 日至 2021 年 11 月 11 日），作为正在进行的辅助研究的一部分。大流行相关问题（非常关心、有些关心、不关心）；体力活动和睡眠变化（较少、较多、相同）；难以获得食物和药物以及常规护理（有、无））是自我报告的。自我报告的身体机能以及情景记忆和工作记忆表现均以 t 分数（得分 50 表示人群平均值，10 分差异表示 1 个标准差）报告，社区活动能力得分范围为 0 至 120，得分越高表示所有领域的功能越好。通过 t 检验和年龄调整、性别调整和种族调整线性回归评估得分差异。
在 245 名参与者中（平均年龄 46 岁；95%女性，77%黑人），报告对大流行感到担忧、体力活动和睡眠减少、难以获得食物和药物以及常规护理的参与者，其身体机能 t 分数（平均=44）始终较低（低 3-5 分）。同样，这些个体的社区活动能力得分（平均=48）也较低（低 10-20 分）。这些个体的情景记忆和工作记忆 t 分数（分别为 50 和 47）没有因大流行相关问题而有明显差异。
我们发现，那些对大流行更加担忧或健康常规受到更大干扰的人，其身体机能和社区活动能力（而非认知能力）较低。未来的研究应该探索针对这些易受影响的 SLE 患者的干预措施，这些患者已经不成比例地遭受功能障碍的困扰，以在危机时期维持功能并预防不良后果。
