Department of Pediatrics, Division of Neonatology, School of Medicine, Aydın Adnan Menderes Universıty, Turkey.
Department of Pediatrics, University of Kyrenia, Cyprus.
Biomed Res Int. 2022 Feb 7;2022:5208993. doi: 10.1155/2022/5208993. eCollection 2022.
Bronchopulmonary dysplasia (BPD) carries a risk of long-term pulmonary sequelae. High-resolution computed tomography (HRCT) is a method of detecting such structural changes. This study is aimed at characterizing structural abnormalities associated with BPD and at evaluating the clinical findings in the newborn period associated with HRCT scores.
28 patients born with a mean gestation age of 30 ± 2.9 weeks and diagnosed as BPD in their neonatal period were reevaluated when they were between the postnatal ages of 6 and 12 months. HRCT was performed in 20 patients with a history of moderate and severe BPD. Scans were interpreted by one radiologist using a scoring system.
Patients were 9.8 ± 2.3 months at the time of reevaluation. The average HRCT score of patients was, respectively, 7.20 ± 4.05 with moderate and 7.40 ± 2.84 with severe BPD. The difference between them was not significant ( = 0.620). When moderate and severe groups were collected as a whole on the basis of physical findings and drug treatment, 6 had normal physical examination findings, no oxygen and no drug requirement; 14 had at least one finding at the time of reevaluation. No significant difference was detected in terms of HRCT score between the two groups (6.50 ± 3.83 versus 7.64 ± 3.30).
More studies are needed in terms of the role of HRCT in the assessment of BPD prognosis. A contemporary definition of BPD that correlates with respiratory morbidity in childhood is needed. Also, a new lung ultrasound technique for predicting the respiratory outcome in patients with BPD can be used instead of HRCT.
支气管肺发育不良（BPD）存在长期肺部后遗症的风险。高分辨率计算机断层扫描（HRCT）是检测此类结构变化的一种方法。本研究旨在描述与 BPD 相关的结构异常，并评估新生儿期与 HRCT 评分相关的临床发现。
28 名患者出生时的平均胎龄为 30 ± 2.9 周，在新生儿期被诊断为 BPD，在出生后 6 至 12 个月时重新评估。20 名有中重度 BPD 病史的患者进行了 HRCT 检查。扫描由一名放射科医生使用评分系统进行解读。
患者在重新评估时的年龄为 9.8 ± 2.3 个月。患者的平均 HRCT 评分为中重度 BPD 分别为 7.20 ± 4.05，重度 BPD 为 7.40 ± 2.84。两者之间的差异无统计学意义（=0.620）。当根据体格检查结果和药物治疗将中重度组作为一个整体收集时，6 例体格检查结果正常，无吸氧和药物需求；14 例在重新评估时有至少一项发现。两组之间的 HRCT 评分无显著差异（6.50 ± 3.83 与 7.64 ± 3.30）。
需要更多研究来评估 HRCT 在 BPD 预后评估中的作用。需要有一个与儿童时期呼吸发病率相关的当代 BPD 定义。此外，一种新的肺部超声技术可用于预测 BPD 患者的呼吸结局，替代 HRCT。
