Leonardi Lucas, Sibéril Sophie, Alifano Marco, Cremer Isabelle, Joubert Pierre-Emmanuel
Inserm UMRS1138, Centre de recherche des Cordeliers, 15 rue de l'École de médecine, 75006 Paris, France - Sorbonne université, Univ Paris 6, France.
Inserm UMRS1138, Centre de recherche des Cordeliers, 15 rue de l'École de médecine, 75006 Paris, France - Département de chirurgie thoracique, Hôpital Cochin, 24 rue du Faubourg Saint-Jacques, AP-HP, 75014 Paris, France.
Med Sci (Paris). 2022 Feb;38(2):159-167. doi: 10.1051/medsci/2022010. Epub 2022 Feb 18.
Autophagy is an important process for cellular homeostasis at critical steps of development or in response to environmental stress. In the context of cancers, autophagy has a significant impact on tumor occurrence and tumor cell growth. On the one hand, autophagy limits the transformation of precancerous cells into cancer cells at an early stage. However, on the other hand, it promotes cell survival, cell proliferation, metastasis and resistance to anti-tumor therapies in more advanced tumors. Autophagy can be induced by a variety of extracellular and intracellular stimulus. Viral infections have often been associated with a modulation of autophagy, with variable impacts on viral replication and on the survival of infected cells depending on the model studied. In a tumor context, the modulation of autophagy induced by the viral infection of tumor cells seems to have a significant impact on tumor progression. The aim of this review article is to present recent findings regarding the consequences of autophagy disturbance by viral infections on tumor behavior.
自噬是细胞在发育关键阶段或应对环境压力时维持细胞稳态的重要过程。在癌症背景下，自噬对肿瘤发生和肿瘤细胞生长有重大影响。一方面，自噬在早期限制癌前细胞向癌细胞的转化。然而，另一方面，在更晚期的肿瘤中，它促进细胞存活、增殖、转移以及对抗肿瘤治疗的抵抗。自噬可由多种细胞外和细胞内刺激诱导。病毒感染常与自噬调节相关，根据所研究的模型，对病毒复制和受感染细胞的存活有不同影响。在肿瘤背景下，肿瘤细胞的病毒感染所诱导的自噬调节似乎对肿瘤进展有重大影响。这篇综述文章的目的是介绍关于病毒感染引起的自噬紊乱对肿瘤行为影响的最新研究结果。
