具有草酰亚胺和酰肼选择性滤器的双（胆酰基）基氯化物通道。
Bis(cholyl)-based chloride channels with oxalamide and hydrazide selectivity filters.
机构信息
Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr Homi Bhabha Road, Pashan, Pune 411008, India.
出版信息
Org Biomol Chem. 2022 Mar 9;20(10):2054-2058. doi: 10.1039/d1ob02028e.
PMID:35179538
Abstract
We report the development of supramolecular bis(cholyl) ion channels using oxalamide and hydrazide as selectivity filters. The hydrazide system showed superior chloride transport activity to oxalamide the formation of a barrel stave channel. The better chloride recognition within the hydrazide channel over the oxalalmide channel was confirmed from the theoretical calculations.
摘要
我们报告了使用草酰胺和酰肼作为选择性过滤器开发超分子双胆堿离子通道。酰肼系统表现出比草酰胺更高的氯离子转运活性，形成了桶板状通道。从理论计算中证实，酰肼通道内对氯离子的识别优于草酰胺通道。
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