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如何培养“新方法学”毒理学家。

How to Foster 'New Approach Methodology' Toxicologists.

机构信息

Edelweiss Connect GmbH, Basel, Switzerland.

Lebanese University, Faculty of Sciences, Hadath, Lebanon.

出版信息

Altern Lab Anim. 2022 Jan;50(1):71-75. doi: 10.1177/02611929221078945. Epub 2022 Feb 18.

Abstract

The need to reduce, refine and replace animal experimentation has led to a boom in the establishment of new approach methodologies (NAMs). This promising trend brings the hope that the replacement of animals by using NAMs will become increasingly accepted by regulators, included in legislation, and consequently more-often implemented by industry. The majority of NAMs, however, are still not very well understood, either due to the complexity of the applied approach or the data analysis workflow. A potential solution to this problem is the provision of better educational resources to scientists new to the area - showcasing the added value of NAMs and outlining various ways of overcoming issues associated with knowledge gaps. In this paper, the educational exchange between four institutions - namely, two universities and two SMEs - via a series of video training sessions, is described. The goal of this exchange was to showcase an exemplary event to help introduce scientists to non-animal approaches, and to actively support the development of resources enabling the use of alternatives to laboratory animals.

摘要

减少、优化和替代动物实验的需求导致了新方法(NAMs)的大量建立。这一有希望的趋势带来了希望,即用 NAMs 替代动物将越来越被监管机构接受,被纳入法规,并因此更频繁地被行业采用。然而,大多数 NAMs 仍然不是很清楚,要么是由于应用方法的复杂性,要么是由于数据分析工作流程。解决这个问题的一个潜在方法是为该领域的新科学家提供更好的教育资源-展示 NAMs 的附加值,并概述克服与知识差距相关的问题的各种方法。本文描述了四所机构(即两所大学和两家中小企业)通过一系列视频培训课程进行的教育交流。这种交流的目的是展示一个典范性的活动,以帮助向科学家介绍非动物方法,并积极支持开发替代实验室动物的资源。

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