Department of Chemistry, Guru Nanak Dev University, Amritsar 143005. India.
Department of Chemistry, Guru Nanak Dev University, Amritsar 143005. India.
Bioorg Chem. 2022 Apr;121:105663. doi: 10.1016/j.bioorg.2022.105663. Epub 2022 Feb 10.
Keeping in view the involvement of inflammation in the pathogenesis of several diseases including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein, we review the processes for the initiation of inflammation and the treatment measures. While focusing on the cyclooxygenase mediated arachidonic acid metabolic pathways, biochemistry of inflammatory prostaglandins is discussed. The data corresponding to efficacy, pharmacokinetic profile and the side effects of the available natural and synthetic anti-inflammatory drugs is reviewed. Moreover, the given information for the drug-based design of new anti-inflammatory agents may help in the development of more potent and safe molecules.
鉴于炎症在包括癌症、糖尿病、神经退行性疾病和类风湿性关节炎在内的多种疾病的发病机制中的作用，我们在此回顾炎症的发生过程和治疗措施。本文重点讨论了环氧化酶介导的花生四烯酸代谢途径，并探讨了炎症性前列腺素的生物化学。综述了现有天然和合成抗炎药物的疗效、药代动力学特征和副作用的数据。此外，这些基于药物的新型抗炎剂设计信息可能有助于开发更有效和更安全的分子。
