Departmento de Biomedicina, Instituto de Ciencias de la Salud, Universidad Veracruzana, Veracruz, Mexico.
Laboratorio D-01, Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
Vitam Horm. 2022;118:289-313. doi: 10.1016/bs.vh.2021.11.007. Epub 2021 Dec 7.
Growth hormone is a multifunctional molecule with broad cellular targets. This pituitary hormone is currently used as a therapeutic agent against several brain injuries due to its neurotrophic activity. The hippocampus is one of the brain regions where the growth hormone plays a role in normal and pathologic conditions. This brain structure is associated with several cognitive functions such as learning, memory, and mood, which are frequently affected by brain traumatism. The present chapter describes the experimental and clinical evidence that supports a central role of growth hormone in the hippocampus functionality.
生长激素是一种具有广泛细胞靶点的多功能分子。由于其神经营养活性，这种垂体激素目前被用作治疗几种脑损伤的药物。海马体是生长激素在正常和病理条件下发挥作用的脑区之一。该脑结构与学习、记忆和情绪等多种认知功能相关，这些功能经常受到脑外伤的影响。本章描述了支持生长激素在海马体功能中的中枢作用的实验和临床证据。
