Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Service of Oral Pathology, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 May;133(5):547-555. doi: 10.1016/j.oooo.2021.08.020. Epub 2021 Aug 30.
Hyperparathyroidism is one of the most common endocrine disorders worldwide. In countries where routine biochemical screening is not common, symptomatic hyperparathyroidism predominates. Its manifestations include skeletal alterations, calcification of soft tissues, kidney stones, and functional alterations in other systems. Notably, jaw alterations can be the first clinical sign of hyperparathyroidism, including brown tumor, renal osteodystrophy, osteitis fibrosa, and leontiasis ossea, and knowing such conditions is of core importance for the multidisciplinary diagnosis and management of hyperparathyroidism. We aimed to perform a concise review, systematizing the concepts and mechanisms underlying hyperparathyroidism and associated gnathic alterations. In addition, a detailed description of the clinical aspects of the jaw manifestations is presented.
甲状旁腺功能亢进症是全世界最常见的内分泌疾病之一。在没有常规生化筛查的国家，症状性甲状旁腺功能亢进症更为常见。其临床表现包括骨骼改变、软组织钙化、肾结石和其他系统的功能改变。值得注意的是，颌骨改变可能是甲状旁腺功能亢进症的首发临床征象，包括棕色瘤、肾性骨营养不良、纤维性骨炎和骨硬化病，了解这些情况对于甲状旁腺功能亢进症的多学科诊断和管理至关重要。我们旨在进行简明的综述，系统地阐述甲状旁腺功能亢进症和相关颌骨改变的概念和机制。此外，还详细描述了颌骨表现的临床方面。
