Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
J Steroid Biochem Mol Biol. 2022 Oct;223:106080. doi: 10.1016/j.jsbmb.2022.106080. Epub 2022 Feb 16.
Studies reporting age-specific reference ranges of endogenous sex steroid hormones in postmenopausal women are relatively scarce. If levels differ by age, dosing and treatment regimens should vary among postmenopausal women accordingly. Our objective was to establish reference ranges for sex steroid hormones and sex hormone binding globulin (SHBG) by age group and overall, and to investigate their association with demographic characteristics. Serum samples were obtained from 1207 healthy postmenopausal women aged 41-92, not using hormone therapy, at the baseline visit of 3 clinical trials. Estrone (E), estradiol (E), and total testosterone (T) were measured by radioimmunoassay with preceding purification steps; SHBG was measured by direct chemiluminescent immunoassay. Free T (FT) was calculated. Women were categorized by 5-year age groups. There was little change in the mean estrogen levels among the different age groups (E: 9-12 pg/mL; E: 33-35 pg/mL). Mean total T levels increased gradually with age from 19.9-26.2 ng/dL, but FT mean levels were relatively constant (3.7-4.6 pg/mL). Mean SHBG levels increased with age from 43-68 nmol/L. A generalized linear model tested the association of each demographic characteristic with the hormones and SHBG. A significant association was derived. Our study provides valuable insight into the profiles of serum sex steroid hormones and SHBG in different healthy postmenopausal women aged 41-92 years.
关于绝经后女性内源性性激素参考范围的研究报告相对较少。如果水平因年龄而异，那么绝经后女性的用药剂量和治疗方案应相应变化。我们的目的是按年龄组和总体建立性激素和性激素结合球蛋白（SHBG）的参考范围，并探讨其与人口统计学特征的关系。在 3 项临床试验的基线访视时，共采集了 1207 名年龄在 41-92 岁、未使用激素治疗的健康绝经后女性的血清样本。采用放射免疫分析法，通过预先进行的纯化步骤测定雌酮（E）、雌二醇（E）和总睾酮（T）；采用直接化学发光免疫分析法测定 SHBG。计算游离睾酮（FT）。将女性按 5 岁年龄组进行分类。不同年龄组的平均雌激素水平变化不大（E：9-12 pg/mL；E：33-35 pg/mL）。总 T 水平随着年龄的增长逐渐升高，从 19.9-26.2ng/dL，但 FT 平均水平相对稳定（3.7-4.6 pg/mL）。SHBG 水平随年龄从 43-68 nmol/L 逐渐升高。广义线性模型测试了每个人口统计学特征与激素和 SHBG 的关联，得出了显著关联。我们的研究为不同年龄段（41-92 岁）健康绝经后女性的血清性激素和 SHBG 特征提供了有价值的见解。
