Lobzin V S, Bagdasarova I A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(2):190-4.
The corticosteroid therapy of multiple sclerosis was modified in relation to the biorhythms of the hypothalamic-pituitary-adrenal axis (HPAA). Prednisolone was prescribed per os in a dose of 1.5 mg/kg bw daily to be taken only in the morning once every three days for 30-45 days. In the control group, prednisolone was administered daily in a dose of 30-60 mg. In the test group, remissions were attained even in hormone-resistant forms of the disease and HPAA function was not seriously affected. Unlike control patients, no severe and persistent complications were observed in that group. The authors believe that the emergence of such complications following the corticosteroid treatment is partially related to the iatrogenic desynchronism of the regulatory biorhythmical processes in the HPAA with the suppression and perversion of adrenal function of steroidogenesis.
多发性硬化症的皮质类固醇疗法根据下丘脑 - 垂体 - 肾上腺轴（HPAA）的生物节律进行了调整。泼尼松龙经口服给药，剂量为每日1.5mg/kg体重，每三天仅在早晨服用一次，持续30 - 45天。在对照组中，泼尼松龙每日剂量为30 - 60mg。在试验组中，即使是激素抵抗型疾病也实现了缓解，且HPAA功能未受到严重影响。与对照组患者不同，该组未观察到严重且持续的并发症。作者认为，皮质类固醇治疗后出现此类并发症部分与HPAA中调节生物节律过程的医源性不同步有关，同时伴有肾上腺类固醇生成功能的抑制和紊乱。
