人乳喂养对早产儿喂养耐受性的影响。
Effect of an exclusive human milk diet on feeding tolerance in preterm infants.
机构信息
Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, 48201, USA.
Department of Pharmacy, Wayne State University, Detroit, MI, 48201, USA.
出版信息
J Perinatol. 2022 Aug;42(8):1070-1075. doi: 10.1038/s41372-022-01348-y. Epub 2022 Feb 18.
OBJECTIVE
To compare the time to full enteral feeds in preterm infants fed exclusive human milk (EHM) - mother's own milk (MOM) fortified with human milk-based fortifier (HMBF), to those who received partial human milk (PHM) - MOM fortified with bovine milk-based fortifier (BMBF), and exclusive formula.
STUDY DESIGN
A single-center retrospective study of infants with birth weight <1250 g from 2013 to 2018. Data on feeding, growth and other short-term neonatal morbidities were collected.
RESULTS
On regression analysis, time to full enteral feeds was significantly higher in PHM compared to EHM group (β-coefficient 4.14, 95% CI 0.00-8.29) and formula-fed group compared to EHM (β-coefficient 4.3, 95% CI 0.32-8.20). No significant differences in growth velocity, length of stay and other morbidities were found between the groups.
CONCLUSION
Infants in EHM had better feeding tolerance and reached their enteral feed goals sooner compared to PHM and formula-fed groups.
目的
比较单纯母乳喂养（EHM）-经人乳强化剂（HMBF）强化的母亲自身奶（MOM）喂养的早产儿与接受部分母乳喂养（PHM）-经牛乳制品强化剂（BMBF）强化的 MOM 喂养以及完全配方奶喂养的早产儿达到全肠内喂养所需的时间。
研究设计
这是一项 2013 年至 2018 年期间在单中心进行的出生体重<1250g 的早产儿回顾性研究。收集了喂养、生长和其他短期新生儿并发症的数据。
结果
回归分析显示，与 EHM 组相比，PHM 组达到全肠内喂养所需的时间显著延长（β系数 4.14，95%CI 0.00-8.29），与 EHM 组相比，配方奶喂养组达到全肠内喂养所需的时间也显著延长（β系数 4.3，95%CI 0.32-8.20）。各组间的生长速度、住院时间和其他并发症无显著差异。
结论
与 PHM 和配方奶喂养组相比，EHM 喂养的婴儿具有更好的喂养耐受性，达到肠内喂养目标的时间更早。
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