Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, United States.
Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States.
J Nutr. 2024 Feb;154(2):610-616. doi: 10.1016/j.tjnut.2023.12.003. Epub 2023 Dec 8.
A common neonatal intensive care unit (NICU) discharge feeding strategy for preterm infants with growth failure who are fed exclusively expressed human milk (EHM) has been to enrich mother's own milk with formula powder or supplement 2-3 feeds per day with formula. However, this strategy displaces human milk from the diet. Our NICU recently adopted the standard practice of adding commercial human milk fortifier (HMF) to human milk feedings after discharge.
We aimed to compare breastfeeding rates and growth using the aforementioned 2 strategies.
Preterm infants (<34 wk of gestation at birth) exclusively feeding EHM fortified with HMF at 2 weeks before discharge were included in this retrospective study. The HMF group (n = 92) continued fortifying with HMF at home, whereas the historical comparison group (n = 35) received our previous guidance to enrich or supplement using postdischarge formula.
Rates of human milk exclusivity after discharge decreased significantly less in the HMF group than those in the historical comparison group (to 83% compared with 39% at the first outpatient visit and 27% compared with 6%, respectively, at the second outpatient visit). Rates of any EHM feedings were also significantly higher in the HMF group. Fenton z-scores for weight, length, and head circumference were not significantly different between the groups.
Continuing EHM fortification with HMF after NICU discharge, rather than enriching or supplementing with postdischarge infant formula, increases rates of feeding EHM for ≥3 mo but does not affect growth.
对于生长不良且仅接受人乳喂养(EHM)的早产儿,一种常见的新生儿重症监护病房(NICU)出院喂养策略是用人乳配方粉强化母乳或每天补充 2-3 次配方奶。然而,这种策略会使母乳从饮食中被取代。我们的 NICU 最近在出院后采用了在人乳喂养中添加商业人乳强化剂(HMF)的标准做法。
我们旨在比较使用上述两种策略的母乳喂养率和生长情况。
这项回顾性研究纳入了在出院前 2 周开始用 HMF 强化 EHM 的早产儿(出生时胎龄<34 周)。HMF 组(n=92)继续在家中强化 HMF,而历史比较组(n=35)则按照我们之前的指导,用出院后配方奶进行强化或补充。
HMF 组出院后人乳喂养的纯母乳喂养率下降幅度明显小于历史比较组(首次门诊就诊时分别降至 83%和 39%,第二次门诊就诊时分别降至 27%和 6%)。HMF 组的任何 EHM 喂养率也明显更高。两组间体重、身长和头围的 Fenton z 评分无显著差异。
与强化或补充出院后配方奶相比,在 NICU 出院后继续用人乳强化剂 HMF 进行强化可以增加至少 3 个月的 EHM 喂养率,但不会影响生长。