Department of Biology, University of Fribourg, Switzerland.
FEBS J. 2022 Jul;289(13):3731-3734. doi: 10.1111/febs.16394. Epub 2022 Feb 20.
Autophagy, a catabolic lysosomal recycling pathway, is often found dysregulated in human diseases. Whereas its prime cell stress-related function is cytoprotection, autophagy has also been linked to the activation of apoptosis and cell death. One group of proteins which participates in the orchestration of autophagy and apoptosis is the family of DRAM proteins. In the current issue of The FEBS Journal, Barthet et al. uncover a compensatory crosstalk between the two newest members of the family, DRAM-4 and DRAM-5, the latter one regulating autophagic activity. Comment on https://doi.org/10.1111/febs.16365.
自噬是一种溶酶体分解代谢的回收途径,在人类疾病中经常发现其失调。尽管它的主要细胞应激相关功能是细胞保护,但自噬也与细胞凋亡和死亡的激活有关。参与自噬和细胞凋亡调控的一组蛋白质是 DRAM 蛋白家族。在本期的《FEBS 杂志》上,Barthet 等人揭示了家族的两个最新成员 DRAM-4 和 DRAM-5 之间的一种补偿性串扰,后者调节自噬活性。评论见 https://doi.org/10.1111/febs.16365。