State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.
Anal Chem. 2022 Mar 1;94(8):3727-3734. doi: 10.1021/acs.analchem.2c00023. Epub 2022 Feb 20.
The real-time tracking and efficacy evaluation of therapeutic nanoplatforms especially in deep-tissues is of great importance but faces challenges. Meanwhile, chemodynamic therapy (CDT), relying on Fenton reaction by converting HO into toxic hydroxyl radicals (•OH), has drawn wide interests in the fabrication of nanozymes for tumor therapy, while endogenous HO is usually insufficient for effective CDT. Here, we report the pH-responsive multifunctional nanoplatforms consisting of copper peroxide (CP) nanoparticles, paclitaxel (PTX) and perfluoro-15-crown-5-ether (PFCE), for F magnetic resonance imaging guided and enhanced chemo-chemodynamic synergetic therapy with self-supplied HO stemmed from the decomposition of CP nanoparticles under acid conditions in tumor. The decomposition of CP nanoparticles further promotes the release of PTX for enhanced chemotherapy. Both in vitro and in vivo results indicate that the efficient generation of •OH and drug release effectively inhibits tumor growth. Furthermore, F MRI signal can clearly track the fate of nanoplatforms in tumor and guide tumor treatment. This work provides a promising strategy for the rational design and construction of multifunctional nanoplatforms for imaging-guided synergistic therapy of deep seated tumor.
治疗性纳米平台的实时跟踪和疗效评估尤其在深部组织中非常重要，但面临挑战。同时，化学动力学疗法（CDT）依赖于 Fenton 反应将 HO 转化为毒性羟基自由基（•OH），在纳米酶用于肿瘤治疗的制备方面引起了广泛关注，而内源性 HO 通常不足以进行有效的 CDT。在这里，我们报告了由过氧化铜（CP）纳米粒子、紫杉醇（PTX）和全氟-15-冠-5-醚（PFCE）组成的 pH 响应多功能纳米平台，用于 F 磁共振成像引导和增强化疗-化学动力学协同治疗，具有自供应 HO，源于 CP 纳米粒子在肿瘤酸性条件下的分解。CP 纳米粒子的分解进一步促进了 PTX 的释放，以增强化疗效果。体外和体内结果均表明，•OH 的有效生成和药物释放可有效抑制肿瘤生长。此外，F MRI 信号可以清楚地跟踪纳米平台在肿瘤中的命运并指导肿瘤治疗。这项工作为构建用于深部肿瘤成像引导协同治疗的多功能纳米平台提供了一个有前景的策略。
