病例系列：新型冠状病毒疫苗接种后急性出血性脑脊髓炎
Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination.
作者信息
Ancau Mihai, Liesche-Starnecker Friederike, Niederschweiberer Johanna, Krieg Sandro M, Zimmer Claus, Lingg Charlotte, Kumpfmüller Daniela, Ikenberg Benno, Ploner Markus, Hemmer Bernhard, Wunderlich Silke, Mühlau Mark, Knier Benjamin
机构信息
Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Department of Neuropathology, Institute of Pathology, Technical University of Munich, Munich, Germany.
出版信息
Front Neurol. 2022 Feb 2;12:820049. doi: 10.3389/fneur.2021.820049. eCollection 2021.
We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.
我们报告了3例符合急性播散性脑脊髓炎出血性变体（急性出血性脑脊髓炎，AHEM）诊断标准的病例，这些病例在接种第一剂ChAdOx1 nCoV-19疫苗后的9天内出现。其中1例通过磁共振成像、脑脊液分析和脑活检确诊为AHEM。与疫苗接种在时间上的密切关联、疾病的免疫相关性以及缺乏其他典型的诱发因素表明，AHEM是一种与疫苗相关的不良反应。我们认为，AHEM可能反映了一种新型的与COVID-19疫苗相关的不良事件，医生对此应保持警惕并提高认识。
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